Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients

Table 7 Univariate and multivariate Cox regression analyses for recurrence-free survival in stage III colon cancers only (n = 268)

Parameters	Univariate analysis			Multivariate analysis
Parameters	HR	95 % C.I.	P ^a	HR	95 % C.I.	P ^a
T stage (T1, 2, 3 vs. T4)	2.97	1.284–6.865	0.011	2.97	1.284–6.865	0.036
N stage (N0, 1 vs. N2)	2.40	1.196–4.795	0.014	2.40	1.196–4.795	0.023
Performance status—LINE-1 methylation
PS(0)/LINE-1 (high)	Ref.			Ref.
PS(0)/LINE-1 (low)	3.69	0.794–17.167	0.096	3.69	0.794–17.167	0.082
PS(≥1)/LINE-1 (high)	1.78	0.297–10.678	0.528	1.78	0.297–10.678	0.528
PS(≥1)/LINE-1 (low)	5.20	1.197–22.611	0.028	5.20	1.197–22.611	0.025

PS performance status
^aCox proportional hazard regression model, adjusted for other selected covariates

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