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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model

Fig. 4

Overexpression of KDM3A/JMJD1A in breast cancer cells and tissues. a Analysis of mentioned histone H3K9 methyltransferases and demethylases by Western blotting; KDM3A/JMJD1A levels gradually increase with transformation. b High expression of KDM3A/JMJD1A in breast cancer cell lines MCF7 and T47D. c Tissue array with paired breast cancer and normal tissues was used for KDM3A staining. d The average KDM3A level in breast cancer tissues is significantly higher than that in the paired normal tissues (n = 48). e Venn diagrams to show that 15 out of 48 paired samples showed both 1.5-fold KDM3A increase and 1.5-fold H3K9me2 decrease in the cancer tissues

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