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Table 3 Cytology according to the Papanicolaou system (Bethesda system) per histological subgroup. Methylation and HPV positivity of the 8 new methylation markers and 4 known markers tested with QMSP in cervical scrapings from patients with CIN0, CIN1, CIN2, CIN3, and (mi)Ca (n = 215)

From: Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3

Cytology

CIN0

CIN 1

CIN2

CIN3

miCa

Pap2 (ASCUS)

9/27 (33 %)

9/38 (24 %)

2/45 (4 %)

0

0

Pap3A (LSIL)

18/27 (66 %)

27/38 (71 %)

36/45 (80 %)

18/61 (30 %)

5/44 (11 %)

Pap3B (HSIL)

0

2/38 (5 %)

6/45 (13 %)

33/61 (54 %)

27/44 (61 %)

Pap4 (HSIL)

0

0

1/45 (2 %)

10/61 (16 %)

8/44 (18 %)

Pap5 (miCa)

0

0

0

0

3/44 (7 %)

Unknown

0

0

0

0

1/44 (2 %)

New genes

     

ZSCAN1

20/27 (74 %)

28/38 (74 %)

41/45 (91 %)

55/61 (90 %)

44/44 (100 %)

ST6GALNAC5

22/27 (82 %)

33/38 (87 %)

39/45 (84 %)

56/61 (92 %)

41/44 (93 %)

ANKRD18CP

3/26 (12 %)

8/36 (22 %)

20/45 (44 %)

33/59 (56 %)

37/43 (86 %)

CDH6

10/26 (39 %)

15/36 (42 %)

25/45 (56 %)

40/59 (68 %)

42/43 (98 %)

GFRA1

1/26 (4 %)

4/36 (11 %)

9/45 (20 %)

23/59 (39 %)

35/43 (81 %)

GATA4

14/26 (54 %)

21/36 (58 %)

35/45 (78 %)

47/59 (80 %)

41/43 (95 %)

KCNIP4

24/27 (89 %)

36/38 (95 %)

44/45 (98 %)

61/61 (100 %)

43/44 (98 %)

LHX8

12/26 (46 %)

20/36 (56 %)

29/45 (64 %)

48/59 (81 %)

41/43 (95 %)

Known genes

     

C13ORF18

2/27 (7 %)

1/38 (3 %)

9/45 (20 %)

24/61 (39 %)

27/44 (61 %)

JAM3

3/27 (11 %)

3/38 (8 %)

18/45 (40 %)

39/61 (64 %)

37/44 (84 %)

EPB41L3

2/27 (7 %)

12/38 (32 %)

18/45 (40 %)

44/61 (72 %)

41/44 (93 %)

TERT

13/27 (48 %)

22/38 (58 %)

29/45 (64 %)

51/61 (84 %)

43/44 (98 %)

HPV test

     

hrHPV

12/26 (46 %)

24/36 (67 %)

36/45 (80 %)

49/59 (83 %)

31/43 (72 %)