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Table 2 Methylation positivity in an external cohort of FFPE samples to validate results of high methylation in CIN2+ lesions and no methylation in normal cervices of the newly found methylation markers

From: Discovery of new methylation markers to improve screening for cervical intraepithelial neoplasia grade 2/3

Gene

Normal

CIN2

CIN3

adCIS

Carcinoma

ZSCAN1

4/16

8/8

7/8

3/3

12/13

ST6GALNAC5

0/16

1/6

4/8

2/3

9/12

ANKRD18CP

0/16

1/8

1/7

2/3

6/12

PAX2

1/14

6/8

7/8

3/3

5/13

CDH6

1/15

3/8

4/8

3/3

7/13

GFRA1

0/12

2/8

3/8

2/3

10/12

POU4F3 a

2/14

6/7

3/7

3/3

11/12

GATA4

0/17

3/8

2/7

3/3

10/13

KCNIP4

0/17

6/8

5/8

3/3

10/12

LHX8

1/16

3/8

4/8

3/3

7/13

  1. aExcluded due to high methylation in leukocytes