Differential 5mC/5hmC status in PCa | Prostate cell type (normal vs. cancer) | Overlapping methylation marks | Genomic region | ||||||
---|---|---|---|---|---|---|---|---|---|
Intergenic | Genic | Exonic | Intronic | Promoter | CpG Island | RWPE-1 DNaseI hypersensitive sites | |||
5hmC “Absent” | RWPE-1 | 5hmC | 0.051 | 0.666 | <0.0001*,** | 0.005*,*** | <0.0001*,** | <0.0001*,** | <0.0001*,** |
22Rv1 | 5mC | <0.0001* | 0.311 | 0.002*,** | 0.001*,*** | <0.0001*,** | <0.0001*,** | <0.0001*,** | |
5hmC “Retained” | RWPE-1 | 5hmC | 0.302 | 0.01 | 0.039 | 0.169 | 0.487 | 0.593 | 0.067 |
22Rv1 | 5hmC | 0.013 | 0.547 | 0.452 | 0.834 | 0.115 | 0.001* | 0.944 | |
5hmC “Gained” | RWPE-1 | 5mC | 0.003*,*** | 0.975 | 0.175 | 0.834 | 0.5 | <0.0001*,** | 0.007* |
22Rv1 | 5hmC | <0.0001*,*** | 0.026 | 0.025 | 0.538 | 0.71 | <0.0001*,** | 0.511 |