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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis

Fig. 4

Locus-specific co-enrichment of methylation and hydroxymethylation marks in normal prostate versus prostate cancer. a Genomic distribution of 5hmC marks exhibiting co-incidence with 5mC in normal prostate versus prostate cancer cells. Co-incident marks were defined as precise regions within the same cell line containing both 5mC and 5hmC marks which exhibited at least partial overlap. be Pathway enrichment annotations from GREAT for co-incident marks in (b) RWPE-1 exonic regions, (c) 22Rv1 intergenic regions, or intronic regions in (d) 22Rv1 or (e) RWPE-1 cells. Log p values for methylation marks (top) and hydroxymethylation marks (bottom) are shown

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