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Table 1 Genes differentially DNA methylated and expressed in fibrotic HIF

From: Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn’s disease-associated fibrosis

Gene symbol

Hyper/hypo

Location of DMR

Fold change (B vs. A)

Adjusted p value

WNT2B

01

Promoter + 5′ UTR + exon + intron

0.19

0

PTGIS

01

Promoter + intron

0.18

0

PTGDS a

10

Promoter + exon

6.44

0.01

COL24A1

01

Promoter + 5′ flank

5.94

0.01

OBSCN

01

Promoter + exon + intron

3.47

0.04

RAB38

01

Promoter + 5′ UTR + exon + 5′ flank

5.73

0

ARL4C

01

Intergenic + promoter + 5′ flank

3.43

0.04

CLIC6

01

Intergenic + promoter + 5′ flank

3.64

0.02

FBLN1

01

Intergenic + promoter + 5′ Flank

0.22

0

KALRN

01

Promoter + 5′ UTR + exon + intron + 5′ flank

3.64

0.03

DCDC2

01

Intergenic + promoter + 5′ flank

25.14

0.01

KCNH2

01

Promoter + exon + intron

0.13

0

IFI27

10

Promoter + 5′ UTR + exon + intron

4.06

0.04

AOC3

10

Promoter + 5′ UTR + exon + intron

0.04

1.16E−15

ADAMTS5

10

Promoter + intron

5.11

0

  1. The genes that were found to be both differentially DNA methylated in their promoter regions and inversely correlated with gene expression are shown. Hyper/hypo column denotes whether genes are yes/no hyper- (01) or hypo- (10) methylated in fibrotic HIF. Italicized 01 and 10 represent genes that were quantitatively differentially DNA methylated and not analyzed further in this study. The location of the DMR, the fold change in mRNA expression detected by RNA-seq, and the adjusted p value are shown
  2. aPTGDS fold change and p values are from RT-PCR validation