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Table 1 Genes differentially DNA methylated and expressed in fibrotic HIF

From: Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn’s disease-associated fibrosis

Gene symbol Hyper/hypo Location of DMR Fold change (B vs. A) Adjusted p value
WNT2B 01 Promoter + 5′ UTR + exon + intron 0.19 0
PTGIS 01 Promoter + intron 0.18 0
PTGDS a 10 Promoter + exon 6.44 0.01
COL24A1 01 Promoter + 5′ flank 5.94 0.01
OBSCN 01 Promoter + exon + intron 3.47 0.04
RAB38 01 Promoter + 5′ UTR + exon + 5′ flank 5.73 0
ARL4C 01 Intergenic + promoter + 5′ flank 3.43 0.04
CLIC6 01 Intergenic + promoter + 5′ flank 3.64 0.02
FBLN1 01 Intergenic + promoter + 5′ Flank 0.22 0
KALRN 01 Promoter + 5′ UTR + exon + intron + 5′ flank 3.64 0.03
DCDC2 01 Intergenic + promoter + 5′ flank 25.14 0.01
KCNH2 01 Promoter + exon + intron 0.13 0
IFI27 10 Promoter + 5′ UTR + exon + intron 4.06 0.04
AOC3 10 Promoter + 5′ UTR + exon + intron 0.04 1.16E−15
ADAMTS5 10 Promoter + intron 5.11 0
  1. The genes that were found to be both differentially DNA methylated in their promoter regions and inversely correlated with gene expression are shown. Hyper/hypo column denotes whether genes are yes/no hyper- (01) or hypo- (10) methylated in fibrotic HIF. Italicized 01 and 10 represent genes that were quantitatively differentially DNA methylated and not analyzed further in this study. The location of the DMR, the fold change in mRNA expression detected by RNA-seq, and the adjusted p value are shown
  2. aPTGDS fold change and p values are from RT-PCR validation