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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn’s disease-associated fibrosis

Fig. 2

Differential gene expression profiles of HIF isolated from normal colons and Crohn’s Disease (CD) fibrotic colons. a Heatmap and hierarchical clustering dendrogram of transcript abundance from RNA-seq performed on HIF RNA from three normal colons and three CD fibrotic colons depicting differentially expressed genes with reduced expression in CD fibrotic colon compared to normal colon. Red represents up-regulation of the gene’s expression, and blue down-regulation. b Heatmap depicting differentially expressed genes with increased expression in CD fibrotic colon compared to normal colon. c Validation by RT-PCR of the fold change in PTGDS, PTGIS, and WNT2B mRNA levels in CD fibrotic versus control fibroblasts is shown (n = 7; PTGDS p = 0.0074, PTGIS p = 0.021, and WNT2B p = 0.015)

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