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Table 5 Univariate and multivariate Cox analyses on overall survival of cancer patients

From: Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites

Ā 

Univariate Cox analysis

Multivariate Cox analysis

Ā 

Hazard ratio [95Ā % CI]

p value

Hazard ratio [95Ā % CI]

p value

Cytology (negative as reference)

Ā Ā Ā Ā 

Positive

1.20 [0.78ā€“1.86]

0.401

Ā Ā 

Suspicious

1.20 [0.68ā€“2.12]

0.528

Ā Ā 

Gender (male as reference)

0.75 [0.51ā€“1.11]

0.153

Ā Ā 

Age (discrete variable)

1.03 [1.01ā€“1.05]

0.002

1.03 [1.01ā€“1.05]

0.002

Cellular SHOX2ā€‰+ā€‰SEPT9

Ā 

0.014*

Ā 

0.017*

Positive (negative as reference)

1.63 [1.02ā€“2.60]

0.039

1.36 [0.84ā€“2.19]

0.211

No DNA (negative as reference)

0.76 [0.48ā€“1.21]

0.250

0.64 [0.40ā€“1.03]

0.065

No DNA (positive as reference)

0.47 [0.28ā€“0.78]

0.004

0.47 [0.28ā€“0.79]

0.005

  1. Results of cellular DNA methylation analyses (nā€‰=ā€‰134). p values indicated by ā€œ*ā€ refer to overall effect of the categorical variables irrespective of the reference levels