Skip to main content

Table 2 Univariate and multivariate Cox analyses on overall survival of ascites patients

From: Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites

Ā 

Univariate Cox analysis

Multivariate Cox analysis

Ā 

Hazard ratio [95Ā % CI]

p value

Hazard ratio [95Ā % CI]

p value

Tumor (negative as reference)

2.28 [1.48ā€“3.53]

<0.001

Ā Ā 

Cytology (negative as reference)

Ā Ā Ā Ā 

Positive

2.10 [1.26ā€“3.51]

0.005

Ā Ā 

Suspicious

1.25 [0.54ā€“2.88]

0.608

Ā Ā 

Gender (male as reference)

0.76 [0.49ā€“1.18]

0.217

Ā Ā 

Age (discrete variable)

1.04 [1.02ā€“1.06]

<0.001

1.04 [1.02ā€“1.06]

<0.001

Cell-free SHOX2ā€‰+ā€‰SEPT9

Ā 

0.002*

Ā 

0.002*

Positive (negative as reference)

2.17 [1.26ā€“3.74]

0.005

2.22 [1.29ā€“3.82]

0.004

No DNA (negative as reference)

0.85 [0.53ā€“1.37]

0.498

0.89 [0.55ā€“1.44]

0.628

No DNA (positive as reference)

0.39 [0.23ā€“0.67]

0.001

0.40 [0.23ā€“0.69]

0.001

  1. Results of cfDNA methylation analyses (nā€‰=ā€‰162). p values indicated by ā€œ*ā€ refer to overall effect of the categorical variables irrespective of the reference levels