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Table 2 Univariate and multivariate Cox analyses on overall survival of ascites patients

From: Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites

  Univariate Cox analysis Multivariate Cox analysis
  Hazard ratio [95 % CI] p value Hazard ratio [95 % CI] p value
Tumor (negative as reference) 2.28 [1.48–3.53] <0.001   
Cytology (negative as reference)     
Positive 2.10 [1.26–3.51] 0.005   
Suspicious 1.25 [0.54–2.88] 0.608   
Gender (male as reference) 0.76 [0.49–1.18] 0.217   
Age (discrete variable) 1.04 [1.02–1.06] <0.001 1.04 [1.02–1.06] <0.001
Cell-free SHOX2 + SEPT9   0.002*   0.002*
Positive (negative as reference) 2.17 [1.26–3.74] 0.005 2.22 [1.29–3.82] 0.004
No DNA (negative as reference) 0.85 [0.53–1.37] 0.498 0.89 [0.55–1.44] 0.628
No DNA (positive as reference) 0.39 [0.23–0.67] 0.001 0.40 [0.23–0.69] 0.001
  1. Results of cfDNA methylation analyses (n = 162). p values indicated by “*” refer to overall effect of the categorical variables irrespective of the reference levels