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Table 1 Univariate and multivariate Cox analyses on overall survival of ascites patients

From: Diagnostic and prognostic value of SHOX2 and SEPT9 DNA methylation and cytology in benign, paramalignant, and malignant ascites

  Univariate Cox analysis Multivariate Cox analysis
  Hazard ratio [95 % CI] p value Hazard ratio [95 % CI] p value
Tumor (negative as reference) 2.24 [1.64–3.05] <0.001 1.87 [1.35–2.59] <0.001
Cytology (negative as reference)     
Positive 1.88 [1.27–2.78] 0.002   
Suspicious 1.54 [0.90–2.63] 0.117   
Gender (male as reference) 0.82 [0.60–1.12] 0.207   
Age (discrete variable) 1.04 [1.02–1.05] <0.001 1.03 [1.02–1.05] <0.001
Cellular SHOX2 + SEPT9   <0.001*   0.003*
Positive (negative as reference) 1.97 [1.30–2.97] 0.001 1.34 [0.87–2.07] 0.182
No DNA (negative as reference) 0.81 [0.58–1.13] 0.212 0.76 [0.54–1.07] 0.121
No DNA (positive as reference) 0.41 [0.26–0.64] <0.001 0.57 [0.36–0.90] 0.015
  1. Results of cellular DNA methylation analyses (n = 283). p values indicated by “*” refer to overall effect of the categorical variables irrespective of the reference levels