CIMP definition | First author (year) | Subgroup | Subgroup size | Analysis | Survival | HR (95Â % CI) | Comparison group | p value | Covariates adjusted for | |
---|---|---|---|---|---|---|---|---|---|---|
CIMP+/CIMP-H | CIMP-L | |||||||||
CRC patients | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 D 2 | Simons (2013) [31] | All | 27 | M | DSS | 3.67 (1.70–7.91)a |  | CIMP− |  | Age, sex, stage, locationb |
 D 2 | Samadder (2013) [30] | All | 563 | M | DSS | 1.06 (0.65–1.35) | 1.19 (0.72–1.97) | CIMP-N | 0.74 | Age, stage, grade, locationc |
 D 4 | Dahlin (2010) [8] | All (NSHDS) | 190 | M | DSS | 1.84 (0.87–3.89) | 2.01 (1.20–3.37) | CIMP-N |  | Age, sex, stage, locationd |
 D 4 | Dahlin (2010) [8] | All (CRUMS) | 414 | M | DSS | 1.10 (0.59–2.03) | 1.48 (1.00–2.22) | CIMP-N |  | Age, sex, stage, locationd |
 D 4 | Dahlin (2011) [24] | All | 484 | M | DSS | 1.09 (0.59–2.03) | 1.47 (0.98–2.20) | CIMP-N |  | Age, sex, stage, locationd |
CRC patients by microsatellite instability | Â | Â | Â | Â | Â | Â | Â | Â | ||
 D 1 | Samowitz (2005) [13] | MSS, colon | 803 | M | DSS | 0.97 (0.70–1.36) |  | CIMP− |  | Age, stage, location, BRAF |
 D 4 | Dahlin (2010) [8] | MSS (NSHDS) | 166 | M | DSS | 3.05 (1.40–6.63) | 1.89 (1.12–3.21) | CIMP-N |  | Age, sex, stage, locationd |
 D 4 | Dahlin (2010) [8] | MSS (CRUMS) | 338 | M | DSS | 1.38 (0.62–3.07) | 1.45 (0.95–2.23) | CIMP-N |  | Age, sex, stage, locationd |
 D 4 | Dahlin (2010) [8] | MSI (CRUMS) | 62 | M | DSS | 1.23 (0.13–11.23) | 3.87 (0.46–32.39) | CIMP-N |  | Age, sex, stage, locationd |
CRC patients by location of CRC | Â | Â | Â | Â | Â | Â | Â | Â | Â | |
 D 4 | Ogino (2009) [19] | Colon | 649 | M | DSS | 0.44 (0.22–0.88) | 0.78 (0.54–1.11) | CIMP-N |  | Age, stage, BRAF, KRAS, MSIe |
 D 1 | Samowitz (2005) [13] | MSS, colon | 803 | M | DSS | 0.97 (0.70–1.36) |  | CIMP− |  | Age, stage, location, BRAF |