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Table 4 Disease-specific survival among patients with colorectal cancer according to CIMP status

From: Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review

CIMP definition First author (year) Subgroup Subgroup size Analysis Survival HR (95 % CI) Comparison group p value Covariates adjusted for
CIMP+/CIMP-H CIMP-L
CRC patients          
 D 2 Simons (2013) [31] All 27 M DSS 3.67 (1.70–7.91)a   CIMP−   Age, sex, stage, locationb
 D 2 Samadder (2013) [30] All 563 M DSS 1.06 (0.65–1.35) 1.19 (0.72–1.97) CIMP-N 0.74 Age, stage, grade, locationc
 D 4 Dahlin (2010) [8] All (NSHDS) 190 M DSS 1.84 (0.87–3.89) 2.01 (1.20–3.37) CIMP-N   Age, sex, stage, locationd
 D 4 Dahlin (2010) [8] All (CRUMS) 414 M DSS 1.10 (0.59–2.03) 1.48 (1.00–2.22) CIMP-N   Age, sex, stage, locationd
 D 4 Dahlin (2011) [24] All 484 M DSS 1.09 (0.59–2.03) 1.47 (0.98–2.20) CIMP-N   Age, sex, stage, locationd
CRC patients by microsatellite instability         
 D 1 Samowitz (2005) [13] MSS, colon 803 M DSS 0.97 (0.70–1.36)   CIMP−   Age, stage, location, BRAF
 D 4 Dahlin (2010) [8] MSS (NSHDS) 166 M DSS 3.05 (1.40–6.63) 1.89 (1.12–3.21) CIMP-N   Age, sex, stage, locationd
 D 4 Dahlin (2010) [8] MSS (CRUMS) 338 M DSS 1.38 (0.62–3.07) 1.45 (0.95–2.23) CIMP-N   Age, sex, stage, locationd
 D 4 Dahlin (2010) [8] MSI (CRUMS) 62 M DSS 1.23 (0.13–11.23) 3.87 (0.46–32.39) CIMP-N   Age, sex, stage, locationd
CRC patients by location of CRC          
 D 4 Ogino (2009) [19] Colon 649 M DSS 0.44 (0.22–0.88) 0.78 (0.54–1.11) CIMP-N   Age, stage, BRAF, KRAS, MSIe
 D 1 Samowitz (2005) [13] MSS, colon 803 M DSS 0.97 (0.70–1.36)   CIMP−   Age, stage, location, BRAF
  1. CI confidence interval, CRUMS and NSHDS are the names of two studies included in Dahlin et al. study, DSS disease-specific survival, HR hazard ratio, M multivariate analysis, U univariate analysis
  2. aData come from early follow-up (≤2 year). Data of late follow-up (>2 year) was 1.41 (0.43–4.57)
  3. bOther covariates included in the multivariate analysis are differentiation grade and initial adjuvant therapy
  4. cOther covariates included in the multivariate analysis are chemotherapy and radiation therapy
  5. dOther covariate included in the multivariate analysis is adjuvant chemotherapy
  6. eOther covariates included in the multivariate analysis are year of diagnosis, sex, site, and tumor grade