Skip to main content

Table 3 Overall survival among patients with colorectal cancer according to CIMP status

From: Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review

CIMP definition First author (year) Subgroup Subgroup size Analysis Survival HR (95 % CI) Comparison group p value Covariates adjusted for
CIMP+/CIMP-H CIMP-L
CRC patients           
 D 1 Lee (2008) [16] All 134 U OS 1.59 (0.87–2.88)   CIMP− 0.13 No
 D 2 Sanchez (2009) [21] All 391 M OS 1.56 (0.88–2.78)a   CIMP− 0.13 Age, sex, stage, location, MSIb
 D 6 Ward (2003) [37] All 609 U OS 1.30 (0.70–2.20)   CIMP− 0.37 No
 D 7 Kakar (2012) [39] All 33 U OS 1.19 (0.51–2.58)   CIMP− 0.69 No
 D 14 Li (2014) [34] All 282 M OS 2.31 (1.02–5.24)   CIMP− 0.04 Age, stage, location, differentiation
 D 2 Samadder (2013) [30] All 563 M OS 1.12 (0.81–1.55) 0.86 (0.60–1.23) CIMP-N 0.60 Age, stage, grade, locationc
 D 3 Kim (2009) [18] All 320 U OS 1.81 (0.91–3.66) 1.33 (0.78–2.27) CIMP-N 0.24 No
 D 4 Kim (2009) [18] All 320 U OS 2.46 (1.16–5.19) 1.30 (0.76–2.22) CIMP-N 0.05 No
 D 14 Li (2014) [34] All 282 M OS 3.06 (1.19–7.89) 0.95 (0.60–1.52) CIMP-N 0.02 Age, stage, location, differentiation
CRC patients by cancer stages
 D 14 Li (2014) [34] I–III 149 M OS 0.52 (0.12–2.22)   CIMP− 0.38 Age, stage, location, differentiation
 D 6 Ward (2003) [37] I–III 476 U OS 1.20 (0.60–2.80)   CIMP− 0.60 No
 D 11 Barault (2008) [14] I–II, colon, MSS 246 M OSd 2.90 (1.53–5.49) 1.85 (1.37–2.51) CIMP-N <0.01 Age, stage, BRAF, KRAS
 D 2 Donada (2013) [40] II, colon 120 M OS 0.60   CIMP− 0.30 All variablese
 D 14 Li (2014) [34] III–IV 129 M OS 1.75 (0.95–3.23)   CIMP− 0.07 Age, stage, location, differentiation
CRC patients by location of CRC
 D 3 Bae (2013) [28] Proximal 165 M OS 0.84 (0.42–1.69)   CIMP− 0.62 Stage, differentiationf
 D 3 Bae (2013) [28] Distal 327 M OS 1.35 (0.47–3.90)   CIMP− 0.58 Stage, differentiationf
 D 4 Ogino (2009) [19] Colon 649 M OS 0.78 (0.47–1.29) 1.01 (0.77–1.33) CIMP-N   Age, sex, stage, BRAF, KRAS, MSIg
 D 2 Donada (2013) [40] Colon, II 120 M OS 0.60   CIMP− 0.30 All variablese
 D 1 Samowitz (2005) [13] Colon, MSS 803 M OS 0.88 (0.66–1.18)   CIMP−   Age, stage, location, BRAF
 D 11 Barault (2008) [14] Colon, MSS, I–II 246 M OSd 2.90 (1.53–5.49) 1.85 (1.37–2.51) CIMP− <0.01 Age, stage, BRAF, KRAS
 D 3 Bae (2013) [28] Rectal 242 M OS 4.13 (1.27–13.46)   CIMP− 0.02 Stage, differentiationf
CRC patients by microsatellite instability
 D 1 Lee (2008) [16] MSS 115 U OS 1.96 (1.06–3.61)   CIMP− 0.03 No
 D 6 Ward (2003) [37] MSS 547 M OS 2.10 (1.10–4.00)   CIMP− 0.02 Stage, vascular space invasion
 D 7 Kakar (2008) [15] MSS 69 M OS 0.86 (0.35–2.13)   CIMP− 0.70 Age, sex, stage, LOH, BRAF
 D 6 Ward (2003) [37] MSS, I–III 464 M OS 2.40 (0.94–6.00)   CIMP− 0.06 Stage, vascular space invasion
 D 1 Samowitz (2005) [13] MSS, colon 803 M OS 0.88 (0.66–1.18)   CIMP−   Age, stage, location, BRAF
 D 11 Barault (2008) [14] MSS, colon, I–II 246 M OSd 2.90 (1.53–5.49) 1.85 (1.37–2.51) CIMP-N <0.01 Age, stage, BRAF, KRAS
CRC patients by microsatellite instability
 D 3 Bae (2011) [23] MSI 169 M OS 2.81 (1.08–7.27)   CIMP− 0.03 Age, stage, BRAF, differentiationh
 D 3 Rhee (2012) [26] MSI 207 M OS 3.05 (1.07–8.73)   CIMP− 0.04 Age, stage, location, BRAF/KRASi
  1. CI confidence interval, HR hazard ratio, M multivariate analysis, OS overall survival, U univariate analysis
  2. aThe original data of HR (95 % CI) was 0.64 (0.36–1.14) derived from CIMP− compared with CIMP+
  3. bOther covariates included in the multivariate analysis are differentiation and chemotherapy
  4. cOther covariates included in the multivariate analysis are chemotherapy and radiation therapy
  5. dRelative survival ratio of observed survival rate to the expected survival rate in a population with similar sex and age distribution derived from local mortality
  6. eOriginal paper mentioned the multivariate analysis including all clinical, pathological, and molecular variables
  7. fOther covariates included in the multivariate analysis are adjuvant chemotherapy
  8. gOther covariates included in the multivariate analysis are year of diagnosis, location, and tumor grade
  9. hOther covariates included in the multivariate analysis are Crohn’s-like lymphoid reaction, peritumoral lymphocytic reaction, and postoperative chemotherapy
  10. iOther covariates included in the multivariate analysis are grade, gross type and Crohn’s-like lymphoid reaction, and peritumoral lymphocytic reaction