Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review

Clinical Epigenetics

Table 2 CIMP definitions and prevalence in studies on survival after specific colorectal cancer therapies according to CIMP status

Definition	First author (year)	Common CIMP genes											Other CIMP genes	CIMP category			CIMP+/-H prevalence
Definition	First author (year)												Other CIMP genes	CIMP+	CIMP−
		CACNA1G	IGF2	NEUROG1	RUNX3	SOCS1	CRABP1	MLH1	p16	MINT1	MINT2	MINT31		CIMP-H	CIMP-L	CIMP-N
D 2	Min (2011) [25]	+	+	+	+	+								≥3/5	1–2/5	0/5	13.9 %
	Donada (2013) [40]	+	+	+	+	+								≥3/5	1–2/5	0/5	18.3 %
	Jo (2012) [44]	+	+	+	+	+								≥3/5	0–2/5		10.0 %
	Shiovitz (2014) [35]	+	+	+	+	+								≥3/5	0–2/5		23.6 %
D 3	Han (2013) [45]	+	+	+	+	+	+	+	+					≥5/8	1–4/8	0/8	7.8 %
D 5	Rijinsoever (2003) [41]								+		+		MDR1	≥2/3	0–1/3		32.5 %
D 8	Jover (2011) [5]	+		+	+	+		+						≥3/5	0–2/5		29.5 %
D 10	Wang (2014) [36]							+	+	+			MGMT, P14^ARF	≥3/5	<3/5		24.0 %
D 14	Li (2014) [34]				+			+	+	+		+	MGMT, APC	≥4/7	1–3/7	0/7	13.1 %
D 15	Ogino (2007) [42]	+	+	+	+	+	+	+	+	+		+	MGMT, IGFBP3, WRN	≥9/13^a	1–8/13	0/13	10.0 %
														≥7/13^b	1–6/13	0/13	16.7 %
D 16	Shen (2007) [43]								+	+		+	P14^ARF	≥2/4	0–1/4		15.4 %

^aCIMP classification 1 of the study. CIMP-H was defined as ≥9/13 methylated markers, CIMP-L as 1/13 to 8/13 methylated markers and CIMP-N as 0/13 methylated markers
^bCIMP classification 2 of the study. CIMP-H was defined as ≥7/13 methylated markers, CIMP-L as 1/13 to 6/13 methylated markers and CIMP-N as 0/13 methylated markers

ISSN: 1868-7083