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Table 4 Linear regression models predicting frailty from relative telomere length (RTL) within tertiles of difference-based methylation age acceleration

From: Frailty is associated with the epigenetic clock but not with telomere length in a German cohort

Stratum of age acceleration Dataset 1 Dataset 2 Overall p a
Tertile 1 (below −1.85 years) 0.132 (−1.253, 1.517) −0.809 (−3.548, 1.930) −0.106 (−1.274, 1.063) 0.86
Tertile 2 (−1.85 to <2.43 years) −0.982 (−2.635, 0.672) −0.404 (−2.266, 1.459) −0.506 (−1.689, 0.678) 0.40
Tertile 3 (≥2.43 years) 0.960 (−0.763, 2.682) −0.135 (−1.881, 1.611) 0.338 (−0.829, 1.504) 0.57
  1. Shown is the estimated change (95 % confidence interval) of the frailty index (expressed in %) per standard deviation of RTL. All models adjusted for age, sex, leukocyte distribution, and random effects of telomere and methylation array batch
  2. a p values refer to t distribution tests of the estimates obtained by multiple imputation in the overall model