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Table 4 Linear regression models predicting frailty from relative telomere length (RTL) within tertiles of difference-based methylation age acceleration

From: Frailty is associated with the epigenetic clock but not with telomere length in a German cohort

Stratum of age acceleration

Dataset 1

Dataset 2

Overall

p a

Tertile 1 (below −1.85 years)

0.132 (−1.253, 1.517)

−0.809 (−3.548, 1.930)

−0.106 (−1.274, 1.063)

0.86

Tertile 2 (−1.85 to <2.43 years)

−0.982 (−2.635, 0.672)

−0.404 (−2.266, 1.459)

−0.506 (−1.689, 0.678)

0.40

Tertile 3 (≥2.43 years)

0.960 (−0.763, 2.682)

−0.135 (−1.881, 1.611)

0.338 (−0.829, 1.504)

0.57

  1. Shown is the estimated change (95 % confidence interval) of the frailty index (expressed in %) per standard deviation of RTL. All models adjusted for age, sex, leukocyte distribution, and random effects of telomere and methylation array batch
  2. a p values refer to t distribution tests of the estimates obtained by multiple imputation in the overall model