From: Frailty is associated with the epigenetic clock but not with telomere length in a German cohort
Covariables | Dataset 1 | Dataset 2 | Overall | p a |
---|---|---|---|---|
None | 0.0013 (−0.0017, 0.0043) | −0.0016 (−0.0044, 0.0012) | 0.0000 (−0.0021, 0.0021) | 1.00 |
Age | −0.0009 (−0.0039, 0.0022) | −0.0031 (−0.0060,−0.0003) | −0.0018 (−0.0039, 0.0003) | 0.094 |
Age, sex | −0.0004 (−0.0035, 0.0027) | −0.0021 (−0.0050, 0.0007) | −0.0011 (−0.0032, 0.0010) | 0.30 |
Age, sex, leucocyte distribution (LD) | 0.0001 (−0.0033, 0.0034) | −0.0014 (−0.0044, 0.0016) | −0.0006 (−0.0028, 0.0017) | 0.63 |
Age, sex, LD, smoking | 0.0001 (−0.0033, 0.0035) | −0.0015 (−0.0046, 0.0015) | −0.0006 (−0.0028, 0.0017) | 0.63 |
Age, sex, LD, alcohol | −0.0002 (−0.0036, 0.0033) | −0.0017 (−0.0048, 0.0015) | −0.0009 (−0.0032, 0.0015) | 0.48 |
Age, sex, LD, history of cancer | 0.0001 (−0.0032, 0.0035) | −0.0017 (−0.0047, 0.0013) | −0.0006 (−0.0029, 0.0016) | 0.58 |
Age, sex, LD, interaction (age accel. with sex) | ||||
Estimate in females | −0.0020 (−0.0064, 0.0023) | −0.0014 (−0.0054, 0.0026) | −0.0011 (−0.0041, 0.0018) | 0.45 |
Estimate in males | 0.0024 (−0.0022, 0.0070) | −0.0014 (−0.0056, 0.0028) | 0.0001 (−0.0030, 0.0032) | 0.96 |