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Fig. 7 | Clinical Epigenetics

Fig. 7

From: Development of 5‘ LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

Fig. 7

5’ LTR and env methylation levels of the HIV-1 provirus in the latent reservoir of long-term treated HIV-1-infected individuals. a The levels of HIV-1 5’ LTR methylation in long-term treated patients. Each diamond represents one patient. The time (years) spent undergoing therapy is depicted on the x-axis whereas the percentage of methylated CpGs in the 5’ LTR of HIV-1 in the latent reservoir of infected patients is depicted on the y-axis. The methylation levels are presented as a mean percentage of methylated CpGs in HIV-1 promoters. b Latent HIV-1 provirus CpG methylation profiles at the 5’ LTR sequences of long-term treated patients nos. LT1 to LT10. The methylation levels are presented as a mean percentage of methylated CpGs (mCpGs) in HIV-1 promoters. An analysis of promoter molecules is shown as a linear array of open circles representing non-methylated CpG residues and closed circles representing methylated CpG residues. Each line represents one sequenced molecule of the 5’ LTR. The rectangle schematically represents the 5’ LTR region U3 with a distribution of individually analyzed CpG dinucleotides and transcription factor binding sites. c Levels of HIV-1 env methylation in selected long-term-treated individuals. The methylation levels are presented as a mean percentage of methylated CpGs mCpGs) in HIV-1 env region. An analysis of env molecules is shown as a linear array of open circles representing non-methylated CpG residues and closed circles representing methylated CpG residues. Each line represents one sequenced env molecule. The rectangle schematically represents the analyzed env region.

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