Table 1 Selected overrepresented gene sets associated with each H3K4me3 pattern

Narrow peak

BioSystems

tRNA metabolic process

28

4.001

1.68E–18

1.29E–14

Narrow peak

BioSystems

Oxidative phosphorylation

11

4.494

1.68E–09

4.39E–07

Narrow peak

KEGG

Exon junction complex (EJC)

4

7.094

8.03E–06

4.46E–04

Narrow peak

BioSystems

RNA polymerase II core binding

4

6.305

1.66E–05

7.59E–04

Upstream extended

MSigDb

FOXM1

38

2.304

2.39E–10

3.68E–06

Upstream extended

MSigDb

PAX4

42

2.003

7.99E–09

3.73E–05

Upstream extended

MSigDb

MYOD

31

2.225

2.09E–08

5.36E–05

Upstream extended

KEGG

Systemic lupus erythematosus

22

1.572

1.07E–03

5.61E–02

Downstream extended

KEGG

Hematopoietic cell lineage

27

14.792

1.24E–30

1.85E–28

Downstream extended

KEGG

Staphylococcus aureus infection

13

9.427

1.98E–13

3.90E–12

Downstream extended

MSigDb

Systemic lupus erythematosus

12

5.216

2.53E–09

2.50E–08

Downstream extended

BioSystems

Response to interferon-alpha

8

8.681

1.23E–08

1.09E–07

Broad symmetric

BioSystems

RORA activates gene expression

11

14.111

1.02E–15

3.65E–14

Broad symmetric

BioSystems

DNA binding, bending

8

12.285

2.28E–11

3.97E–10

Broad symmetric

MSigDb

HMX1

10

6.987

9.52E–11

1.48E–09

Broad symmetric

KEGG

Systemic lupus erythematosus

18

2.198

4.11E–06

2.44E–05