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Fig. 5 | Clinical Epigenetics

Fig. 5

From: H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus

Fig. 5

H3K4me3 patterns of increased gene transcription in SLE. a The distributions of H3K4me3 changes at genes with increased transcription were different among three nearby regions after their dependence on each other was removed. Each bar defines the number of genes and the x-axis displays the magnitude of H3K4me3 change. b The TSS H3K4me3 of genes with increased transcription in SLE had the most increase at ~700 bp. The dotted lines represent TSS and the peak summit. c Relative change of H3K4me3 at upstream and downstream of TSS is often shadowed by higher level of H3K4me3 at TSS when sequencing depth of control and patient samples was plotted separately (upper panel), and becomes more prominent when the relative depth difference is plotted (lower panel). TDP2 encodes a protein associated with major regulators of immune response, such as CD40, TNF, and TRAFs. Its transcription was significantly increased by 96 % in SLE (p = 0.004). We encourage readers to use our online tool (see “Methods” section) to make similar plots of their genes of interest

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