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Table 4 CpG–metabotype associations at the three replicated loci. Only associations with metabotypes that were significant at P value <1.3 × 10−5 (Bonferroni correction of testing multiple metabolic traits) are shown; effect size (beta′), P value of the linear model, and number of samples (N) (data from Supplementary Table 5 of [38]; for details on this dataset, see there)

From: Epigenetic associations of type 2 diabetes and BMI in an Arab population

Metabolic trait cg06500161 (ABCG1) cg00574958 (CPT1A) cg19693031 (TXNIP)
Beta′ P value N Beta′ P value N Beta′ P value N
1-Oleoylglycerol (1-monoolein) 9.435 2.84 × 10−11 1676 −0.983 4.37 × 10−11 1676 −0.841 1.02 × 10−14 1674
Alpha-hydroxybutyrate (AHB) 1.834 7.80 × 10−6 1749 −0.926 1.30 × 10−10 1749 −0.574 7.24 × 10−8 1747
3-methyl-2-oxovalerate 0.771 1.31 × 10−5 1749 −0.605 4.50 × 10−5 1749 −0.472 6.81 × 10−13 1747
Glycine −0.531 2.91 × 10−6 1744 4.064 7.58 × 10−9 1744 0.656 4.91 × 10−6 1742
Palmitoylcarnitine 1.729 1.35 × 10−5 1737 −0.849 2.28 × 10−6 1737 −0.579 3.11 × 10−8 1735
PC aa C36:4 2.549 2.82 × 10−5 1781 −0.947 2.07 × 10−8 1781 −0.628 1.66 × 10−6 1779
PC aa C42:0 −0.883 3.91 × 10−8 1781 22.276 3.36 × 10−6 1781 6.181 1.11 × 10−13 1779
PC aa C42:1 −0.844 4.63 × 10−7 1781 12.688 4.18 × 10−5 1781 4.631 4.93 × 10−12 1779
PC ae C44:6 −0.918 8.52 × 10−12 1781 17.438 4.88 × 10−6 1781 5.075 5.48 × 10−13 1779
Chylo-A (nM) 594.7 8.44 × 10−14 1773 −1.000 1.35 × 10−13 1773 −0.996 1.11 × 10−21 1771
Chylo-B (nM) 29.53 7.09 × 10−6 1766 −1.000 3.24 × 10−12 1766 −0.988 8.30 × 10−18 1764
Chylo-Rem (nM) 416.1 1.34 × 10−11 1772 −1.000 2.38 × 10−12 1772 −0.991 5.40 × 10−15 1770
IDL (nM) 30.86 1.32 × 10−9 1773 −0.993 6.00 × 10−7 1773 −0.868 2.22 × 10−7 1771
VLDL-A (nM) 150.7 2.72 × 10−13 1773 −1.000 9.23 × 10−14 1773 −0.985 5.73 × 10−19 1771
VLDL-B (nM) 166.0 4.22 × 10−13 1773 −1.000 9.83 × 10−12 1773 −0.979 9.24 × 10−16 1771