Table 4 CpG–metabotype associations at the three replicated loci. Only associations with metabotypes that were significant at P value <1.3 × 10−5 (Bonferroni correction of testing multiple metabolic traits) are shown; effect size (beta′), P value of the linear model, and number of samples (N) (data from Supplementary Table 5 of [38]; for details on this dataset, see there)
From: Epigenetic associations of type 2 diabetes and BMI in an Arab population
Metabolic trait | cg06500161 (ABCG1) | cg00574958 (CPT1A) | cg19693031 (TXNIP) | ||||||
|---|---|---|---|---|---|---|---|---|---|
Beta′ | P value | N | Beta′ | P value | N | Beta′ | P value | N | |
1-Oleoylglycerol (1-monoolein) | 9.435 | 2.84 × 10−11 | 1676 | −0.983 | 4.37 × 10−11 | 1676 | −0.841 | 1.02 × 10−14 | 1674 |
Alpha-hydroxybutyrate (AHB) | 1.834 | 7.80 × 10−6 | 1749 | −0.926 | 1.30 × 10−10 | 1749 | −0.574 | 7.24 × 10−8 | 1747 |
3-methyl-2-oxovalerate | 0.771 | 1.31 × 10−5 | 1749 | −0.605 | 4.50 × 10−5 | 1749 | −0.472 | 6.81 × 10−13 | 1747 |
Glycine | −0.531 | 2.91 × 10−6 | 1744 | 4.064 | 7.58 × 10−9 | 1744 | 0.656 | 4.91 × 10−6 | 1742 |
Palmitoylcarnitine | 1.729 | 1.35 × 10−5 | 1737 | −0.849 | 2.28 × 10−6 | 1737 | −0.579 | 3.11 × 10−8 | 1735 |
PC aa C36:4 | 2.549 | 2.82 × 10−5 | 1781 | −0.947 | 2.07 × 10−8 | 1781 | −0.628 | 1.66 × 10−6 | 1779 |
PC aa C42:0 | −0.883 | 3.91 × 10−8 | 1781 | 22.276 | 3.36 × 10−6 | 1781 | 6.181 | 1.11 × 10−13 | 1779 |
PC aa C42:1 | −0.844 | 4.63 × 10−7 | 1781 | 12.688 | 4.18 × 10−5 | 1781 | 4.631 | 4.93 × 10−12 | 1779 |
PC ae C44:6 | −0.918 | 8.52 × 10−12 | 1781 | 17.438 | 4.88 × 10−6 | 1781 | 5.075 | 5.48 × 10−13 | 1779 |
Chylo-A (nM) | 594.7 | 8.44 × 10−14 | 1773 | −1.000 | 1.35 × 10−13 | 1773 | −0.996 | 1.11 × 10−21 | 1771 |
Chylo-B (nM) | 29.53 | 7.09 × 10−6 | 1766 | −1.000 | 3.24 × 10−12 | 1766 | −0.988 | 8.30 × 10−18 | 1764 |
Chylo-Rem (nM) | 416.1 | 1.34 × 10−11 | 1772 | −1.000 | 2.38 × 10−12 | 1772 | −0.991 | 5.40 × 10−15 | 1770 |
IDL (nM) | 30.86 | 1.32 × 10−9 | 1773 | −0.993 | 6.00 × 10−7 | 1773 | −0.868 | 2.22 × 10−7 | 1771 |
VLDL-A (nM) | 150.7 | 2.72 × 10−13 | 1773 | −1.000 | 9.23 × 10−14 | 1773 | −0.985 | 5.73 × 10−19 | 1771 |
VLDL-B (nM) | 166.0 | 4.22 × 10−13 | 1773 | −1.000 | 9.83 × 10−12 | 1773 | −0.979 | 9.24 × 10−16 | 1771 |