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Table 3 Meta-analyses of the replicated loci in the Qatari study with the TwinsUK results

From: Epigenetic associations of type 2 diabetes and BMI in an Arab population

Trait

Probe (gene)

Qatari cohort

TwinsUK cohort

Meta-analysis

Beta

SE

p value

Beta

SE

p value

Beta (95U/95 L)

SE

p value

I 2 (%)

T2D

cg19693031 (TXNIP)

−2.41

0.57

2.46 × 10−5

−0.34

0.12

6.74 × 10−3

−0.43 (−0.66/−0.20)

0.12

2.71 × 10-4

92.1

BMI

cg18181703 (SOCS3)

−10.78

2.34

3.99 × 10−6

−2.90

0.71

5.45 × 10−5

−3.56 (−4.90/−2.23)

0.68

1.59 × 10−7

90.4

cg11024682 (SREBF1)

14.56

3.56

4.33 × 10−5

5.86

0.91

2.12 × 10−10

6.39 (4.67/8.12)

0.88

4.28 × 10−13

82.2

cg07573872 (SBNO2)

−9.96

2.48

5.87 × 10−5

−2.64

0.81

1.16 × 10−3

−3.35 (−4.85/−1.84)

0.77

1.41 × 10−5

87.3

cg00574958 (CPT1A)

−21.04

5.33

7.99 × 10−5

−12.43

1.90

1.08 × 10−10

−13.40 (−16.91/−9.89)

1.79

7.32 × 10−14

56.8

cg07136133 (PRR5L)

−10.43

2.79

1.85 × 10−4

−3.82

0.78

8.02 × 10−7

−4.36 (−5.84/−2.89)

0.75

6.43 × 10−9

80.4

cg03078551 (NA)

−19.23

5.85

1.00 × 10−3

−7.35

1.43

3.36 × 10−7

−8.02 (−10.74/−5.30)

1.39

7.97 × 10−9

74.3

cg13123009 (LY6G6E)

12.41

3.80

1.10 × 10−3

3.06

1.06

3.81 × 10−3

3.74 (1.73/5.74)

1.02

2.56 × 10−4

82.2

  1. The table reports the results we obtained using a fixed effects model with inverse variance to combine the regression coefficients of each study and their standard errors. P values, effect sizes (beta), and their standard errors (SE) are reported for both studies and for the meta-analysis results. For the meta-analysis, we also reported: upper/lower 95 % CI for beta (beta 95U/95L), and heterogeneity estimates (I 2)