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Table 3 Meta-analyses of the replicated loci in the Qatari study with the TwinsUK results

From: Epigenetic associations of type 2 diabetes and BMI in an Arab population

Trait Probe (gene) Qatari cohort TwinsUK cohort Meta-analysis
Beta SE p value Beta SE p value Beta (95U/95 L) SE p value I 2 (%)
T2D cg19693031 (TXNIP) −2.41 0.57 2.46 × 10−5 −0.34 0.12 6.74 × 10−3 −0.43 (−0.66/−0.20) 0.12 2.71 × 10-4 92.1
BMI cg18181703 (SOCS3) −10.78 2.34 3.99 × 10−6 −2.90 0.71 5.45 × 10−5 −3.56 (−4.90/−2.23) 0.68 1.59 × 10−7 90.4
cg11024682 (SREBF1) 14.56 3.56 4.33 × 10−5 5.86 0.91 2.12 × 10−10 6.39 (4.67/8.12) 0.88 4.28 × 10−13 82.2
cg07573872 (SBNO2) −9.96 2.48 5.87 × 10−5 −2.64 0.81 1.16 × 10−3 −3.35 (−4.85/−1.84) 0.77 1.41 × 10−5 87.3
cg00574958 (CPT1A) −21.04 5.33 7.99 × 10−5 −12.43 1.90 1.08 × 10−10 −13.40 (−16.91/−9.89) 1.79 7.32 × 10−14 56.8
cg07136133 (PRR5L) −10.43 2.79 1.85 × 10−4 −3.82 0.78 8.02 × 10−7 −4.36 (−5.84/−2.89) 0.75 6.43 × 10−9 80.4
cg03078551 (NA) −19.23 5.85 1.00 × 10−3 −7.35 1.43 3.36 × 10−7 −8.02 (−10.74/−5.30) 1.39 7.97 × 10−9 74.3
cg13123009 (LY6G6E) 12.41 3.80 1.10 × 10−3 3.06 1.06 3.81 × 10−3 3.74 (1.73/5.74) 1.02 2.56 × 10−4 82.2
  1. The table reports the results we obtained using a fixed effects model with inverse variance to combine the regression coefficients of each study and their standard errors. P values, effect sizes (beta), and their standard errors (SE) are reported for both studies and for the meta-analysis results. For the meta-analysis, we also reported: upper/lower 95 % CI for beta (beta 95U/95L), and heterogeneity estimates (I 2)