| |
H19 DMR
|
MEG3 DMR
|
SGCE/PEG10 DMR
|
PLAGL1 DMR
|
|---|
| |
mean methylation % (standard deviation)
|
|---|
| |
47.93 (3.82)
|
72.64 (5.55)
|
45.98 (5.17)
|
57.79 (6.33)
|
|---|
|
Maternal B vitamins
|
β coefficient, Standard Error, p value
|
|---|
|
B12
| | | | |
|
≤322.47 ng/L
|
Reference
|
Reference
|
Reference
|
Reference
|
|
322.48–446.04 ng/L
|
0.53, 0.57, 0.35
|
0.53, 0.85, 0.53
|
0.01, 0.66, 0.98
|
0.39, 0.95, 0.68
|
|
446.05–575.51 ng/L
|
0.68, 0.56, 0.22
|
0.01, 0.82, 0.99
|
0.26, 0.66, 0.70
|
0.58, 0.94, 0.54
|
|
>575.51 ng/L
|
−0.41, 0.57, 0.48
|
−0.93, 0.85, 0.27
|
0.47, 0.67, 0.48
|
1.79, 0.96, 0.06
|
|
PLP
| | | | |
|
≤3.76 nM/L
|
Reference
|
Reference
|
Reference
|
Reference
|
|
3.77–7.47 nM/L
|
−0.15, 0.60, 0.80
|
0.23, 0.83, 0.79
|
0.99, 0.75, 0.19
|
−0.02, 0.98, 0.99
|
|
7.48–12.05 nM/L
|
−0.68, 0.62, 0.28
|
2.01, 0.89, 0.03
|
−0.33, 0.79, 0.68
|
−0.26, 1.02, 0.80
|
|
>12.05 nM/L
|
−0.07, 0.63, 0.91
|
3.24, 0.89, <0.01
|
−0.30, 0.81,0.71
|
−0.11, 1.04, 0.91
|
|
PA
| | | | |
|
≤2.06 nM/L
|
Reference
|
Reference
|
Reference
|
Reference
|
|
2.07–3.21 nM/L
|
−0.45, 0.58, 0.44
|
−0.18,0.84, 0.83
|
1.46, 0.74, 0.05
|
1.27, 0.95,0.18
|
|
3.22–5.93 nM/L
|
−0.09, 0.60, 0.88
|
−0.24, 0.87, 0.79
|
0.79, 0.75, 0.29
|
1.54, 0.98, 0.12
|
|
>5.93 nM/L
|
−0.57, 0.61,0.35
|
1.62, 0.87, 0.06
|
0.08, 0.78, 0.92
|
−0.15, 0.99, 0.88
|
|
Hcy
| | | | |
|
≤4.40 umol/L
|
Reference
|
Reference
|
Reference
|
Reference
|
|
4.41–5.10 umol/L
|
1.01, 0.59, 0.09
|
1.49, 0.87, 0.09
|
1.43, 0.77, 0.06
|
1.46, 0.98, 0.14
|
|
5.11–6.00 umol/L
|
−0.97, 0.58, 0.10
|
1.07, 0.86, 0.21
|
1.19, 0.76, 0.12
|
1.77, 0.97, 0.07
|
|
>6.00 umol/L
|
0.19, 0.60, 0.75
|
1.60, 0.87, 0.07
|
1.36, 0.79, 0.09
|
1.10, 0.98, 0.27
|
- Adjusted for gestational age at delivery, gestational age at blood draw, maternal race/ethnicity, maternal smoking and pre-pregnancy body mass index
-
DMR differentially methylated region, B
12
vitamin B12, PLP pyridoxal phosphate, PA 4-pyridoxic acid, Hcy homocysteine
