Skip to main content

Table 4 Adjusted regression coefficients for maternal B vitamins and infant differentially methylated regions: Newborn Epigenetic STudy (N = 429)

From: Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains

  H19 DMR MEG3 DMR SGCE/PEG10 DMR PLAGL1 DMR
  mean methylation % (standard deviation)
  47.93 (3.82) 72.64 (5.55) 45.98 (5.17) 57.79 (6.33)
Maternal B vitamins β coefficient, Standard Error, p value
B12     
 ≤322.47 ng/L Reference Reference Reference Reference
 322.48–446.04 ng/L 0.53, 0.57, 0.35 0.53, 0.85, 0.53 0.01, 0.66, 0.98 0.39, 0.95, 0.68
 446.05–575.51 ng/L 0.68, 0.56, 0.22 0.01, 0.82, 0.99 0.26, 0.66, 0.70 0.58, 0.94, 0.54
 >575.51 ng/L −0.41, 0.57, 0.48 −0.93, 0.85, 0.27 0.47, 0.67, 0.48 1.79, 0.96, 0.06
PLP     
 ≤3.76 nM/L Reference Reference Reference Reference
 3.77–7.47 nM/L −0.15, 0.60, 0.80 0.23, 0.83, 0.79 0.99, 0.75, 0.19 −0.02, 0.98, 0.99
 7.48–12.05 nM/L −0.68, 0.62, 0.28 2.01, 0.89, 0.03 −0.33, 0.79, 0.68 −0.26, 1.02, 0.80
 >12.05 nM/L −0.07, 0.63, 0.91 3.24, 0.89, <0.01 −0.30, 0.81,0.71 −0.11, 1.04, 0.91
PA     
 ≤2.06 nM/L Reference Reference Reference Reference
 2.07–3.21 nM/L −0.45, 0.58, 0.44 −0.18,0.84, 0.83 1.46, 0.74, 0.05 1.27, 0.95,0.18
 3.22–5.93 nM/L −0.09, 0.60, 0.88 −0.24, 0.87, 0.79 0.79, 0.75, 0.29 1.54, 0.98, 0.12
 >5.93 nM/L −0.57, 0.61,0.35 1.62, 0.87, 0.06 0.08, 0.78, 0.92 −0.15, 0.99, 0.88
Hcy     
 ≤4.40 umol/L Reference Reference Reference Reference
 4.41–5.10 umol/L 1.01, 0.59, 0.09 1.49, 0.87, 0.09 1.43, 0.77, 0.06 1.46, 0.98, 0.14
 5.11–6.00 umol/L −0.97, 0.58, 0.10 1.07, 0.86, 0.21 1.19, 0.76, 0.12 1.77, 0.97, 0.07
 >6.00 umol/L 0.19, 0.60, 0.75 1.60, 0.87, 0.07 1.36, 0.79, 0.09 1.10, 0.98, 0.27
  1. Adjusted for gestational age at delivery, gestational age at blood draw, maternal race/ethnicity, maternal smoking and pre-pregnancy body mass index
  2. DMR differentially methylated region, B 12 vitamin B12, PLP pyridoxal phosphate, PA 4-pyridoxic acid, Hcy homocysteine