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Table 2 Adjusted regression coefficients for maternal B vitamins and birth weight by infant sex: Newborn Epigenetic STudy (N = 496)

From: Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains

   Infant sex
  All participants (N = 496) Male infants (N = 248) Female infants (N = 248)
Maternal B vitamin β coefficient, standard error, p value
B12    
 ≤322.47 ng/L Reference Reference Reference
 322.48–446.04 ng/L −12.89,70.83, 0.86 59.38, 104.12,0.58 −29.38, 101.01,0.77
 446.05–575.51 ng/L −35.89, 69.24, 0.60 −59.18, 105.57,0.58 13.55, 95.10, 0.88
 >575.51 ng/L 1.85, 69.82, 0.98 108.19, 100.01,0.28 −63.02, 99.61,0.53
 p for interaction 0.5276
PLP    
 ≤3.76 nM/L Reference Reference Reference
 3.77–7.47 nM/L −72.75, 71.50, 0.31 3.37, 106.39, 0.97 −126.43, 102.07, 0.22
 7.48–12.05 nM/L −45.61, 73.22, 0.53 −28.02, 114.15, 0.81 −15.02, 99.25, 0.88
 >12.05 nM/L 39.81, 75.75, 0.60 43.48, 119.08,0.72 56.05, 100.69, 0.58
 p for interaction 0.7014
PA    
 ≤2.06 nM/L Reference Reference Reference
 2.07–3.21 nM/L −13.80,70.48, 0.84 −50.67, 108.60, 0.64 49.43, 96.66, 0.61
 3.22–5.93 nM/L −35.02,70.51,0.62 −7.31, 107.61,0.95 −36.80, 95.43,0.70
 >5.93 nM/L 9.95, 72.43, 0.89 16.03, 112.20, 0.89 35.43, 97.44, 0.72
 p for interaction 0.9134
Hcy    
 ≤4.40 umol/L Reference Reference Reference
 4.41–5.10 umol/L −57.72, 70.94, 0.42 −143.95, 108.74, 0.19 27.65, 95.21, 0.77
 5.11–6.00 umol/L −72.86,71.21,0.31 −275.57, 105.70,0.01 76.91, 98.03, 0.43
 >6.00 umol/L −87.21, 70.48, 0.22 −210.40, 102.08, 0.04 27.33, 98.14, 0.78
 p for interaction 0.1021
  1. Adjusted for gestational age at delivery, gestational age at blood draw, maternal pre-pregnancy body mass index, maternal race/ethnicity, parity, household income and maternal smoking
  2. B 12 vitamin B12, PLP pyridoxal phosphate, PA 4-pyridoxic acid, Hcy homocysteine