| |
Traita
|
|---|
|
T2D
|
FBG
|
FPI
|
HOMA-IR
|
|---|
|
Model specification
|
|
Type of trait
|
Discrete
|
Continuous
|
Continuous
|
Continuous
|
|
Transformation
|
Liability
|
Inverse normalization
|
Inverse normalization
|
Inverse normalization
|
|
Covariate setb
|
A
|
B
|
B
|
B
|
|
Association with HTGW
|
|
b (95 % CI)
|
0.65 (0.39–0.90)
|
0.30 (0.17–0.43)
|
0.16 (0.02–0.29)
|
0.26 (0.13–0.38)
|
|
P
|
3.7 × 10−7
|
1.2 × 10−5
|
0.0236
|
9.8 × 10−5
|
|
Association of HTGW and its components estimated through an interactive model
|
|
High TG and WC
| | | | |
|
b (95 % CI)
|
0.87 (0.31–1.43)
|
0.45 (0.22–0.68)
|
0.32 (0.08–0.56)
|
0.45 (0.22–0.67)
|
|
P
|
0.0021
|
0.0001
|
0.0079
|
8.0 × 10−5
|
|
High WC only
| | | | |
|
b (95 % CI)
|
0.25 (0.13-0.37)
|
0.16 (0.04-0.29)
|
0.17 (−0.18-0.52)
|
0.20 (0.00-0.39)
|
|
P
|
5.9 × 10−5
|
0.0081
|
0.3472
|
0.0399
|
|
High TG only
| | | | |
|
b (95 % CI)
|
0.22 (−1.66–2.09)
|
0.24 (−1.79–2.28)
|
0.28 (−0.86–1.43)
|
0.37 (−0.62–1.37)
|
|
P
|
0.8194
|
0.8160
|
0.6284
|
0.4612
|
-
HTGW hypertriglyceridemic waist, TG Triglycerides, WC Waist circumference, b regression coefficient, p significance value
-
a
T2D type 2 diabetes, FBG fasting blood glucose, FPI fasting plasma insulin, HOMA-IR homeostatic model of assessment—insulin resistance
-
b
Covariate set A, age, age2, sex, age × sex interaction, age2 × sex interaction, body mass index, systolic and diastolic blood pressure, use of anti-lipid and anti-hypertensive medications; Covariate Set B age, age2, sex, age × sex interaction, age2 × sex interaction, body mass index, systolic and diastolic blood pressure, use of anti-lipid, anti-hypertensive, and anti-diabetic medications
