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Table 1 Independent association of HTGW with T2D-related traits in San Antonio Family Heart Study participants

From: Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families

  Traita
T2D FBG FPI HOMA-IR
Model specification
Type of trait Discrete Continuous Continuous Continuous
Transformation Liability Inverse normalization Inverse normalization Inverse normalization
Covariate setb A B B B
Association with HTGW
b (95 % CI) 0.65 (0.39–0.90) 0.30 (0.17–0.43) 0.16 (0.02–0.29) 0.26 (0.13–0.38)
P 3.7 × 10−7 1.2 × 10−5 0.0236 9.8 × 10−5
Association of HTGW and its components estimated through an interactive model
High TG and WC     
b (95 % CI) 0.87 (0.31–1.43) 0.45 (0.22–0.68) 0.32 (0.08–0.56) 0.45 (0.22–0.67)
P 0.0021 0.0001 0.0079 8.0 × 10−5
High WC only     
b (95 % CI) 0.25 (0.13-0.37) 0.16 (0.04-0.29) 0.17 (−0.18-0.52) 0.20 (0.00-0.39)
P 5.9 × 10−5 0.0081 0.3472 0.0399
High TG only     
b (95 % CI) 0.22 (−1.66–2.09) 0.24 (−1.79–2.28) 0.28 (−0.86–1.43) 0.37 (−0.62–1.37)
P 0.8194 0.8160 0.6284 0.4612
  1. HTGW hypertriglyceridemic waist, TG Triglycerides, WC Waist circumference, b regression coefficient, p significance value
  2. a T2D type 2 diabetes, FBG fasting blood glucose, FPI fasting plasma insulin, HOMA-IR homeostatic model of assessment—insulin resistance
  3. b Covariate set A, age, age2, sex, age × sex interaction, age2 × sex interaction, body mass index, systolic and diastolic blood pressure, use of anti-lipid and anti-hypertensive medications; Covariate Set B age, age2, sex, age × sex interaction, age2 × sex interaction, body mass index, systolic and diastolic blood pressure, use of anti-lipid, anti-hypertensive, and anti-diabetic medications