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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families

Fig. 1

Manhattan plots showing the genome-wide association of DNA sequence variants and epigenome-wide association of DNA methylation with liability of HTGW. a Genome-wide association study. Genome-wide significance is indicated by the red horizontal line and chromosomal locations are color-coded. Results are from polygenic regression models that accounted for age, age2, sex, age × sex interaction, and age2 × sex interaction, the top four principal components quantifying ancestry-based population admixture, and use of anti-lipid, anti-hypertensive and anti-diabetic medications. b Epigenome-wide association study. Epigenome-wide significance is indicated by the red horizontal line. Significantly associated CpG sites are labeled and chromosomal locations are color-coded. Results are from polygenic regression models adjusted for age, age2, sex, age × sex interaction, and age2 × sex interaction, Illumina Sentrix® ID and Sentrix® position (to account for batch effects), estimated cell counts, and use of anti-lipid, anti-hypertensive and anti-diabetic medications. Q-Q plots corresponding to Panel A and B are shown in Additional file 2: Figures S1 and S2, respectively

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