DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder

Clinical Epigenetics

Table 4 Overlap between DMRs and regions implicated in schizophrenia by a recent large-scale GWAS [28]

PGC SCZ region^a	DMR coordinates^a	DMR gene(s)	DMR comparison	DMR p value	DMR direction^b
Chr10:18681005-18770105	Chr10:18688985-18689948	CACNB2	LH vs. MI	1.84 × 10⁻⁴	Up
Chr22: 42548710-42548874	Chr22: 42548710-42548874	–	LH vs. MI	1.49 × 10⁻⁵	Up
Chr22: 42548710-42548874	Chr22: 42548710-42548874	–	ULH vs. MI	1.85 × 10⁻⁵	Up
Chr11: 109285471-109610071	Chr11: 109294141-109294239	C11orf87	ALH vs. ULH	5.32 × 10⁻⁵	Up
Chr6: 28303247-28712247	Chr6: 28555640-28559522	Extended MHC	ULH vs. MI	1.37 × 10⁻⁴	Down

^ahg19/GRCh37
^b“Up” indicates hypermethylation and “down” indicates hypomethylation compared to the reference group

ISSN: 1868-7083