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Fig. 3 | Clinical Epigenetics

Fig. 3

From: “Monoallelic germline methylation and sequence variant in the promoter of the RB1 gene: a possible constitutive epimutation in hereditary retinoblastoma”

Fig. 3

a This pattern of methylation found in the melanoma suggests hemizigosity which probably corresponds to the presence of the maternal-methylate allele and to the absence (loss of heterozygosity) of the paternal allele. This pattern contrasts with that in b observed in PBL of the index case and his siblings which suggests monoallelic methylation. c The bracket included clearly shows the difference of methylation between “C” and “W” clones

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