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Table 5 Univariate Cox regression overall and recurrence-free survival analysis

From: MicroRNA-100 and microRNA-21 as markers of survival and chemotherapy response in pancreatic ductal adenocarcinoma UICC stage II

Variable

Subset

Overall survival

Recurrence-free survival

  

Hazard ratio (95 % CI)

p value

Hazard ratio (95 % CI)

p value

PTEN

low/high

3.095 (1.5502–6.1805)

0.0014

2.7944 (1.4826–5.2669)

0.0015

DCK

low/high

0.5536 (0.2772–1.1057)

0.0939

0.5178 (0.2813–0.9532)

0.0345

HuR

low/high

0.6799 (0.3448–1.3409)

0.2656

0.6569 (0.3559–1.2125)

0.1789

MDR-1

low/high

2.2213 (1.1291–4.3698)

0.0208

2.5516 (1.3799–4.7179)

0.0028

MRP-1

low/high

2.0104 (0.9778–4.1331)

0.0576

2.5762 (1.3334–4.9773)

0.0049

BCRP-1

low/high

2.7438 (1.3117–5.7395)

0.0074

3.9656 (1.9563–8.0385)

0.0001

VEGF-1

low/high

1.5977 (0.6059–4.2123)

0.3435

1.3889 (0.6157–3.1331)

0.4286

N

N0/N1

1.2670 (0.6269–2.5605)

0.5096

1.16965 (0.6213–2.2018)

0.6273

G

G3/G1-2

0.9045 (0.4425–1.8491)

0.7833

0.7767 (0.4036–1.4946)

0.4492

L

L0/L1

1.2793 (0.6478–2.5264)

0.4781

1.1996 (0.6541–2.1998)

0.5565

V

V0/V1

1.4841 (0.6944–3.1716)

0.3083

1.7039 (0.8545–3.3975)

0.1301

Pn

Pn0/Pn1

1.3512 (0.6629–2.7538)

0.4073

1.2389 (0.6426–2.3889)

0.5224

R

0/1

1.3996 (0.6839–2.8644)

0.3576

1.8921 (0.9923–3.6081)

0.0528

gender

f/m

0.9404 (0.4784–1.8487)

0.8586

1.0039 (0.5444–1.8513)

0.9899

age

>65/≤65

0.7334 (0.3747–1.4354)

0.3655

0.7598 (0.4142–1.3938)

0.3749

operation

DP/PD

1.1089 (0.5034–2.4431)

0.7974

1.2319 (0.5889–2.5774)

0.5796

CTX response

good/bad

23.3621 (5.5057–99.1321)

0.00002

159.7685 (11.1902–2281.0912)

0.0002

microRNA-21

low/high

(2.3127) (1.1218–4.7675)

0.0231

2.2006 (1.1256–4.3022)

0.0211

microRNA-31*

low/high

1.4769 (0.7365–2.9614)

0.2719

1.7738 (0.9362–3.3606)

0.0788

microRNA-99

low/high

2.2291 (1.0399–4.7781)

0.0393

1.5775 (0.8023–3.1019)

0.1864

microRNA-100

low/high

4.0097 (1.7189–9.3536)

0.0013

2.3653 (1.1714–4.7762)

0.0163

microRNA-125b

low/high

2.1879 (0.9745–4.9127)

0.0578

2.0935 (1.0093–43426)

0.0472

microRNA-138

low/high

1.4770 (0.6583–3.3141)

0.3442

1.3268 (0.6556–2.6854)

0.4318

microRNA-147b

low/high

0.8217 (0.4094–1.6489)

0.5805

0.7387 (0.3891–1.4022)

0.3543

microRNA-148a

low/high

0.9135 (0.4533–1.8411)

0.8003

1.1714 (0.6249–2.1957)

0.6217

microRNA-210

low/high

2.4021 (1.1408–5.0578)

0.0211

2.2881 (1.1611–4.5091)

0.0168

microRNA-376a

low/high

1.9456 (0.9518–3.9771)

0.0681

1.7029 (0.8906–3.2563)

0.1075

  1. Indication of hazard ratio and 95 % confidence interval (CI). p < 0.05 indicates significance