Table 2 Summary of the genetic and epigenetic results in the four classes of CRC
From: Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer
| Â | LS-MSI | S-MSI | S-MSS | EO-MSS | p value |
|---|---|---|---|---|---|
| Â | No. of tumors/totala (%) | Â | |||
LINE-1 methylation |  |  |  |  | 2 × 10−5 |
 L1 (>60.1 %) | 17/69 (25) | 15/28 (54) | 14/97 (14) | 5/23 (22) |  |
 L2 (54.1–60 %) | 28/69 (40) | 7/28 (25) | 22/97 (23) | 6/23 (26) |  |
 L3 (45.8–54 %) | 22/69 (32) | 6/28 (21) | 40/97 (41) | 9/23 (39) |  |
 L4 (<45.6 %) | 2/69 (3) | 0/28 (0) | 21/97 (22) | 3/23 (13) |  |
Gene methylation |  |  |  |  | 10−12 |
 Cluster 1 | 59/71 (83) | 6/28 (16) | 59/98 (60) | 19/23 (83) |  |
 Cluster 2 | 7/71 (10) | 3/28 (11) | 26/98 (27) | 3/23 (13) |  |
 Cluster 3 | 5/71 (7) | 19/28 (73) | 13/98 (13) | 1/23 (4) |  |
CIN | 0/9 (0) | 1/6 (17) | 12/16 (75) | 3/6 (50) | 4.9 × 10−3 |
TP53 deletion | 0/9 (0) | 1/6 (17) | 6/16 (31) | 3/6 (50) | 0.10 |
KRAS mutation | 25/58 (43) | 0/26 (0) | 28/94 (30) | 7/23 (30) | 1.2 × 10−3 |
BRAF V600E mutation | 0/71 (0) | 18/27 (67) | 2/93 (2) | 0/23 (0) | <10−4 |