Fig. 2
From: Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer
a Supervised clustering analysis with k-means algorithm identifies four clusters showing significant differences of LINE-1 methylation levels: L1 (51 CRCs, mean 63.1 %), L2 cluster (63 CRCs, mean 57.2 %), L3 cluster (77 CRCs, mean 50.9 %), and L4 cluster (26 CRCs, mean 40.2 %); b Kaplan-Meier curves showing significantly different clinical outcome in patients stratified by tumor LINE-1 methylation groups (p = 5 × 10−4)