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Table 3 DNA methylation and time to disease (TTD)

From: Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

   ZBTB12      LINE-1     
TTD classa Rangeb Effect size 95 % CI se P TREND Cochran’s Q Effect size 95 % CI se P TREND Cochran’s Q
EPICOR men           
 TTD class 1 8.89–14.66           
 TTD class 2 5.23–8.88 −0.0054 −0.0090;−0.0018 0.0018 0.0036   −0.0009 −0.0016;−0.0003 0.0003 0.0044  
 TTD class 3 0.26–5.20           
EPIC-NL men           
 TTD class 1 6.97–12.31           
 TTD class 2 3.53–6.86 −0.0093 −0.0182;−0.0005 0.0045 0.0389   −0.0035 −0.0070;0.00003 0.0018 0.0537  
 TTD class 3 0.23–3.52           
Meta-analysis −0.0059 −0.0093;−0.0027 0.0017 0.0005 0.65c −0.0010 −0.0017;−0.0004 0.0003 0.0016 2.03c
EPICOR women           
 TTD class 1 8.16–14.02           
 TTD class 2 4.40–8.06 −0.0056 −0.0106;−0.0007 0.0025 0.0250   −0.0008 −0.0017;0.00004 0.0004 0.0636  
 TTD class 3 0.33–4.30           
EPIC-NL women           
 TTD class 1 7.35–12.30           
 TTD class 2 4.40–7.21 −0.0047 −0.0106;0.0011 0.0030 0.1147   −0.0011 −0.0032;0.0010 0.0011 0.2970  
 TTD class 3 0.04–4.38           
Meta-analysis −0.0053 −0.0091;−0.0015 0.0019 0.0065 0.05c −0.0008 −0.0016;−0.0001 0.0004 0.0263 0.07c
  1. aHealthy controls (TTD class 0) were used as the reference group. Cases were divided in tertiles (TTD classes 1 to 3)
  2. bMinimum and maximum TTD (i.e., time lapse in years from enrollment to occurrence of MI) for each class
  3. cd.f. = 1, P = not significant
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