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Table 1 EPICOR and EPIC-NL sample descriptive

From: Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk

  EPICOR men    EPICOR women    EPIC-NL men EPIC-NL women   
  Cases Controls    Cases Controls    Cases Controls Cases Controls   
  (N = 188) (N = 188)    (N = 104) (N = 104)    (N = 116) (N = 83) (N = 201) (N = 179)   
  n (%) n (%)    n (%) n (%)    n (%) n (%) n (%) n (%)   
Center               
 Varese 42 (22.34) 42 (22.34)    67 (65.69) 67 (65.69)         
 Ragusa 19 (10.11) 19 (10.11)    3 (2.94) 3 (2.94)         
 Turin 127 (67.55) 127 (67.55)    23 (22.55) 23 (22.55)         
 Naples    11 (10.78) 11 (10.78)         
 Utrecht          149 (74.13) 140 (78.21)   
 Bilthoven          116 (100) 83 (100) 52 (25.87) 39 (21.79)   
Smoking status               
 Never 33 (17.55) 50 (26.60)   53 (50.96) 73 (70.19)   19 (16.38) 18 (21.69) 60 (29.85) 85 (47.49)  
 Former 70 (37.23) 87 (46.28) * 11 (10.58) 13 (12.50) * 34 (29.31) 32 (38.55) 48 (23.88) 48 (26.81) *
 Current 85 (45.21) 51 (27.13)   40 (38.46) 18 (17.31)   62 (53.45) 33 (39.76) 89 (44.28) 45 (25.14)  
 NA          1 (0.86)   4 (1.99) 1 (0.56)   
Menopausal Status               
 Premenopause      27 (25.96) 26 (25.00)      43 (21.39) 42 (23.46)   
 Post-menopause      77 (74.04) 78 (75.00)      158 (78.61) 137 (76.54)   
  Mean ± sd Mean ± sd    Mean ± sd Mean ± sd    Mean ± sd Mean ± sd Mean ± sd Mean ± sd   
Age at recruitment (years) 50.98 ± 6.93 50.92 ± 7.01    55.02 ± 7.40 55.01 ± 7.51    51.51 ± 7.68 51.11 ± 8.30 58.56 ± 8.74 59.30 ± 8.12   
Avg. follow-up (years) 12.98 ± 2.29 13.26 ± 2.06    12.24 ± 1.97 12.66 ± 1.16    13.07 ± 5.21 15.25 ± 2.31** 11.61 ± 4.92 14.27 ± 2.62**   
Avg. TTD (years) 7.14 ± 3.88    6.54 ± 3.57    5.44 ± 3.22 5.76 ± 3.06   
BMI (kg/m2) 27.05 ± 2.96 26.35 ± 3.12**    26.95 ± 4.69 25.93 ± 5.11    27.12 ± 3.30 27.08 ± 3.15 26.47 ± 4.24 26.05 ± 4.17   
WHR 0.94 ± 0.06 0.93 ± 0.06**    0.83 ± 0.06 0.79 ± 0.06**    0.95 ± 0.08 0.94 ± 0.08 0.82 ± 0.07 0.80 ± 0.07**   
Total cholesterol (mmol/L) 6.10 ± 1.12 5.86 ± 1.22    6.42 ± 1.23 6.36 ± 1.16    6.24 ± 0.95 5.79 ± 0.97** 5.51 ± 0.98 5.27 ± 0.98**   
LDL cholesterol (mmol/L) 3.94 ± 1.00 3.60 ± 1.01**    4.07 ± 1.15 3.97 ± 1.01    3.60 ± 0.94 3.34 ± 0.92 3.44 ± 0.82 3.19 ± 0.77**   
HDL cholesterol (mmol/L) 1.30 ± 0.29 1.48 ± 0.37**    1.55 ± 0.39 1.76 ± 0.41**    1.11 ± 0.28 1.12 ± 0.28 1.16 ± 0.33 1.27 ± 0.36**   
Triglycerides (mmol/L) 1.89 ± 0.99 1.71 ± 1.04    1.74 ± 1.43 1.38 ± 0.57**    2.28 ± 1.27 2.28 ± 1.46 1.77 ± 0.98 1.54 ± 0.91**   
SBP (mmHg) 137.47 ± 16.56 135.04 ± 19.03    144.36 ± 9.77 136.76 ± 10.08**    134.43 ± 17.61 128.51 ± 14.93** 138.50 ± 22.23 133.59 ± 20.76**   
DBP (mmHg) 85.38 ± 8.96 84.97 ± 10.80    86.08 ± 22.13 84.97 ± 19.02    84.96 ± 10.71 80.60 ± 10.19** 81.99 ± 11.20 79.22 ± 11.18**   
Alcohol (gr/day) 23.46 ± 20.26 24.98 ± 20.90    6.29 ± 10.78 8.76 ± 15.43    19.42 ± 21.89 18.41 ± 22.27 7.55 ± 11.24 8.44 ± 12.21   
  1. LDL low-density lipoprotein, HDL high-density lipoprotein, SBP systolic blood pressure, DBP diastolic blood pressure, TTD time to disease, WHR waist-to-hip ratio
  2. *Chi-square test P < 0.05; **t test P < 0.05
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