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Table 3 Univariate Cox regression survival analysis of the iCluster classification DNAm (iCC-DNAm) and mRNA (iCC-mRNA) centroids in ER+ breast cancer, as well as that of the luminal subtype classification (Lum-A/B)

From: The integrative epigenomic-transcriptomic landscape of ER positive breast cancer

  iCC-DNAm   iCC-mRNA   Lum-A/B  
  HR (95 % CI) P HR (95 % CI) P HR (95 % CI) P
TCGA 1.83 ( 0.86–3.90) 0.112 1.83 (0.86–3.90) 0.112 2.68 (1.20–5.99) 0.012
METABRIC NA NA 1.45 (1.20–1.75) 0.0001 1.82 (1.49–2.21) 2e-9
Germany 2.31 (1.07–4.99) 0.028 NA NA NA NA
Fleischer 2.38 (0.81–6.97) 0.103 2.03 (0.64–6.37) 0.217 0.97 (0.23–3.58) 0.961
Combined Fisher test P   0.013   0.0002   7e-9
  1. NA not available due to missing information
  2. Hazard Ratios (HR), 95 % confidence intervals (CI) and likelihood ratio test P values in each data set are given. The P values under a combined Fisher test is also given
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