Skip to main content

Table 3 Univariate Cox regression survival analysis of the iCluster classification DNAm (iCC-DNAm) and mRNA (iCC-mRNA) centroids in ER+ breast cancer, as well as that of the luminal subtype classification (Lum-A/B)

From: The integrative epigenomic-transcriptomic landscape of ER positive breast cancer

 

iCC-DNAm

 

iCC-mRNA

 

Lum-A/B

 
 

HR (95 % CI)

P

HR (95 % CI)

P

HR (95 % CI)

P

TCGA

1.83 ( 0.86–3.90)

0.112

1.83 (0.86–3.90)

0.112

2.68 (1.20–5.99)

0.012

METABRIC

NA

NA

1.45 (1.20–1.75)

0.0001

1.82 (1.49–2.21)

2e-9

Germany

2.31 (1.07–4.99)

0.028

NA

NA

NA

NA

Fleischer

2.38 (0.81–6.97)

0.103

2.03 (0.64–6.37)

0.217

0.97 (0.23–3.58)

0.961

Combined Fisher test P

 

0.013

 

0.0002

 

7e-9

  1. NA not available due to missing information
  2. Hazard Ratios (HR), 95 % confidence intervals (CI) and likelihood ratio test P values in each data set are given. The P values under a combined Fisher test is also given