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Table 2 GSEA on FEM modules revealed strong enrichment of two FEMs with seed genes CAV1 and FSTL1, respectively

From: The integrative epigenomic-transcriptomic landscape of ER positive breast cancer

FEM

Size

Enriched pathway

Overlap

Overlapping genes

CAV1

58

WNT signalling

23

DKK1 WNT3A FZD9 WNT2 WNT7A IGFBP4

FZD8 FZD1 LRP6 FZD2 LRP5 FZD6 RSPO1

WNT5A RYK FZD5 ATP6AP2 WNT3 WIF1

WNT1 WNT7B FZD10 SFRP1

FSTL1

56

TGF-beta signalling

18

NOG GDF5 CHRD TGFB2 TGFB1 FST TGFB3

BMPR2 GDF6 BMPR1A BMPR1B ACVRL1

ACVR2A BMP4 BMP2 BMP7 BMP6 INHBE

  1. Columns label the FEM module size, the main enriched pathway, the number of overlapping genes between FEM and pathway and the overlapping genes