Fig. 6

FEM module genes exhibit coordinated DNAm changes. a Binary matrix representation of two FEM modules, with rows labelling genes and columns labelling ER+ breast cancers. In the heatmap, blue indicates that the gene’s DNAm level in the given cancer sample deviates significantly from the normal tissue values. b Comparison of the observed average Manhattan distance between FEM module genes (red vertical line), as estimated from the binary matrix representations in (a), to the distribution of average Manhattan distances obtained by permuting the samples within each row (1000 permutations, green density curves). Empirical P value for the observed distance is given