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Table 1 Demographics and clinical characteristics of the patients and samples analyzed in this study

From: Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer

 

Adenomas

Carcinomas

Metastases

Carcinomas vs. Metastases

Number

42

210

70

Age

n = 42

n = 210

n = 66

 

 Mean ± SD

64.2 ± 11.4

65.1 ± 14.1

62.5 ± 11.5

p = 0.12

 Range

30–80

18–93

33–86

 

Gender

n = 42

n = 210

n = 66

 

 Female

13 (31 %)

98 (47 %)

28 (40 %)

 

 Male

29 (69 %)

112 (53 %)

38 (54 %)

p = 0.57

 Information not available

  

4 (6 %)

 

Race

n = 27

n = 161

n = 63

 

 Caucasian

18 (43 %)

125 (60 %)

57 (81 %)

 

 African-American

9 (21 %)

36 (17 %)

6 (9 %)

p = 0.035

 Other/not well defined

15 (36 %)

49 (23 %)

7 (10 %)

 

Locationa

n = 40

n = 210

n = 32

 

 Proximal

27 (64 %)

110 (52 %)

9 (13 %)

 

 Distal

13 (31 %)

100 (48 %)

23 (33 %)

p = 0.013

 Information not available

2 (5 %)

0

38 (54 %)

 

Stage (Dukes’)

 

n = 210

  

 A

NA

18 (9 %)

NA

 

 B

NA

77 (37 %)

NA

 

 C

NA

59 (28 %)

NA

 

 D

NA

56 (27 %)

NA

 

Grade

 

n = 202

n = 32

 

 Well/moderate

NA

156 (74 %)

32 (46 %)

 

 Poor

NA

46 (22 %)

2 (3 %)

p = 0.021

 Information not available

NA

8 (4 %)

36 (51 %)

 

Mucinous phenotype

 

n = 210

n = 70

 

 Non-mucinous

 

151 (72 %)

57 (81 %)

 

 Mucinous

 

59 (28 %)

13 (19 %)

p = 0.15

MSI

n = 41

n = 208

n = 62

 

 MSS

40 (95 %)

185 (88 %)

62 (89 %)

 

 MSI

1 (2 %)

23 (11 %)

0

p = 0.003

 Information not available

1 (2 %)

2 (1 %)

8 (11 %)

 

TP53

n = 33

n = 191

n = 42

 

 WT

28 (67 %)

104 (50 %)

18 (26 %)

 

 MUT

5 (12 %)

87 (41 %)

24 (34 %)

p = 0.23

 Information not available

9 (21 %)

19 (9 %)

28 (40 %)

 

KRAS

n = 42

n = 195

n = 50

 

 WT

19 (45 %)

117 (56 %)

32 (46 %)

 

 MUT

23 (55 %)

78 (37 %)

18 (26 %)

p = 0.63

 Information not available

0

15 (7 %)

20 (29 %)

 

BRAF

n = 12

n = 175

n = 34

 

 WT

12 (29 %)

153 (73 %)

32 (46 %)

 

 MUT

0

22 (10 %)

2 (3 %)

p = 0.38

 Information not available

30 (71 %)

35 (17 %)

36 (51 %)

 
  1. For every parameter, the number of cases with information is indicated (n=)
  2. NA not applicable
  3. aIn the metastases column, location refers to the originating primary lesion when known
  4. P values of the comparison between carcinomas and metastases were obtained by Fisher’s test except for Age, where Student’s t test was applied