|
Gene
|
Gene feature
|
Chr
|
hg19 coordinates
|
Probes
|
Minimal p value
|
Mean p value
|
Maximal difference in methylation change (%)a
|
|---|
|
DIRAS3
|
5′UTR,1stExon,TSS200
|
1
|
68516080-68516627
|
11
|
0.0095
|
0.0175
|
5.2
|
|
–
|
–
|
6
|
85478576-85478807
|
2
|
0.0155
|
0.0210
|
3.6
|
|
NODAL
|
3′UTR
|
10
|
72191686-72191804
|
2
|
0.0198
|
0.0231
|
2.3
|
|
ARMC8
|
TSS1500,TSS200
|
3
|
137905836-137906122
|
7
|
0.0361
|
0.0400
|
1.3
|
|
PRDM16
|
Body
|
1
|
3130485-3130550
|
3
|
0.0361
|
0.0361
|
2.8
|
|
GNA12
|
Body
|
7
|
2801424-2801732
|
3
|
0.0387
|
0.0437
|
−2.4
|
- The DMRs were identified using the DMRcate package available through Bioconductor. The p values considered the false discovery rate and were adjusted using the Benjamini-Hochberg procedure. The minimal and mean p value as well as the maximal difference in DNA methylation change were calculated based on the indicated number of probes for each region. aThe maximal difference was calculated for the DNA methylation change after intervention with folic acid and vitamin B12 versus placebo. Abbreviations: Chr chromosome, DMR differentially methylated region, h19 coordinates for the human genome based on the Genome Reference Consortium Human Build 37 (hg19/GRCh37), TSS200 200 base pairs around the transcription start site, TSS1500 1500 base pairs around the transcription start site, 3′UTR 3′ untranslated region, 5′UTR 5′ untranslated region
