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Table 1 MS-associated CpGs in CD8+ T cells

From: Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients

Probe IDa

CHRb

Position

Genec

Feature

Median (case)

Median (control)

Δ meth d

p valuee

cg03431738

21

40031295

ERG

5′UTR

0.81

0.68

0.13

0.004033

cg12026095

19

49468461

FTL

TSS200

0.30

0.49

−0.18

0.004033

cg26228123

14

73392919

DCAF4

TSS200

0.09

0.20

−0.11

0.004033

cg10478035

13

80919503

 

-

0.75

0.64

0.11

0.004033

cg04474988

10

131770171

 

-

0.34

0.46

−0.11

0.03549

cg25152348

22

50946712

NCAPH2

1st exon

0.30

0.47

−0.17

0.03549

cg08206623

11

2907334

CDKN1C

TSS1500

0.29

0.44

−0.15

0.004033

cg13738615

9

109624741

ZNF462

TSS1500

0.18

0.31

−0.13

0.004033

cg01525244

22

39548611

CBX7

TSS200

0.14

0.24

−0.10

0.004033

cg12702165

12

95228136

MIR492

TSS200

0.65

0.54

0.11

0.004033

cg06443542

10

100206752

HPS1

TSS200

0.14

0.25

−0.11

0.03549

cg00380172

6

148663585

SASH1

TSS200

0.21

0.33

−0.12

0.03549

cg19095187

6

108437051

 

-

0.17

0.31

−0.14

0.03549

cg04488145

3

46899455

MYL3

3′UTR

0.83

0.73

0.11

0.03549

cg03027241

20

49620453

KCNG1

3′UTR

0.50

0.32

0.18

0.004033

cg11700985

10

82127205

DYDC2

3′UTR

0.85

0.74

0.11

0.03549

cg07886142

5

126793022

MEGF10

3′UTR

0.59

0.46

0.13

0.03549

cg18183163

2

171574141

SP5

3′UTR

0.12

0.26

−0.14

0.03549

cg01181415

12

16757954

LMO3

5′UTR

0.22

0.36

−0.14

0.03549

cg10143811

12

16757985

LMO3

5′UTR

0.12

0.22

−0.10

0.03549

cg23274123

1

229478617

C1orf96

5′UTR

0.10

0.22

−0.12

0.004033

cg00095276

5

1068111

SLC12A7

Body

0.77

0.63

0.15

0.004033

cg03447557

1

2273735

MORN1

Body

0.80

0.70

0.10

0.03549

cg02745847

17

47075880

IGF2BP1

Body

0.17

0.31

−0.13

0.03549

cg09406795

11

64019655

PLCB3

Body

0.25

0.38

−0.13

0.000358

cg18016288

13

95834131

ABCC4

Body

0.47

0.32

0.15

0.000358

cg14486346

2

102000131

CREG2

Body

0.78

0.66

0.12

0.03549

cg21937244

14

103406412

CDC42BPB

Body

0.75

0.61

0.14

0.03549

cg11811840

2

234669166

UGT1A10

Body

0.84

0.72

0.12

0.03549

cg25756617

1

43734917

TMEM125

TSS1500

0.69

0.58

0.11

0.03549

cg03768916

10

49813307

ARHGAP22

TSS200

0.30

0.43

−0.14

0.004033

cg06524757

13

72441523

DACH1

TSS200

0.25

0.35

−0.11

0.03549

cg03168749

11

124413574

OR8B12

TSS200

0.82

0.68

0.14

0.03549

cg21276022

9

136390236

TMEM8C

TSS200

0.74

0.61

0.13

0.004033

cg09851596

8

143545214

BAI1

TSS200

0.60

0.49

0.11

0.03549

cg25296222

11

2037173

 

-

0.76

0.65

0.11

0.03549

cg00878533

1

2848864

 

-

0.72

0.62

0.11

0.000358

cg03612700

17

18970610

 

-

0.64

0.52

0.12

0.004033

cg03310594

7

22704316

 

-

0.82

0.69

0.13

2.34E-05

cg05854694

14

61123243

 

-

0.12

0.22

−0.10

0.000358

cg12384499

15

89949617

 

-

0.19

0.31

−0.11

0.004033

cg22509113

2

91777482

 

-

0.41

0.51

−0.10

0.004033

cg10495084

15

96889416

 

-

0.24

0.36

−0.12

0.004033

cg18008019

13

100641646

 

-

0.10

0.23

−0.12

0.03549

cg12093775

13

112548065

 

-

0.15

0.26

−0.11

0.000358

cg12787323

10

119494959

 

-

0.16

0.27

−0.11

0.004033

cg22792862

14

67827087

EIF2S1

1st exon

0.23

0.38

−0.15

0.004033

cg08969532

10

99790438

CRTAC1

1st exon

0.05

0.15

−0.10

0.004033

cg18185028

3

154042079

DHX36

1st exon

0.30

0.41

−0.11

0.000358

cg23059965

19

50655862

C19orf41

3′UTR

0.81

0.70

0.11

0.004033

cg02192678

8

1495185

DLGAP2

5′UTR

0.78

0.68

0.11

0.004033

cg02976009

6

32068226

TNXB

5′UTR

0.71

0.59

0.12

0.03549

cg18073471

4

81119198

PRDM8

5′UTR

0.18

0.29

−0.11

0.03549

cg00945810

7

814391

HEATR2

Body

0.67

0.56

0.11

0.03549

cg04875614

4

2008706

WHSC2

Body

0.80

0.69

0.10

2.34E-05

cg26920627

1

7319248

CAMTA1

Body

0.75

0.63

0.12

0.004033

cg26647242

2

30040525

ALK

Body

0.78

0.67

0.11

0.004033

cg04605816

20

62092443

KCNQ2

Body

0.83

0.71

0.12

0.004033

cg10944063

2

120233706

SCTR

Body

0.58

0.46

0.12

0.004033

cg14595269

7

151216272

RHEB

Body

0.14

0.24

−0.10

2.34E-05

cg23720125

5

177097760

LOC202181

Body

0.85

0.73

0.12

0.004033

cg02047661

3

51976883

RRP9

TSS1500

0.64

0.52

0.11

0.004033

cg07925549

12

52828840

KRT75

TSS1500

0.75

0.63

0.12

0.03549

cg06697094

17

54911185

DGKE

TSS1500

0.16

0.28

−0.12

0.03549

cg18789663

1

242688591

PLD5

TSS1500

0.09

0.20

−0.11

0.03549

cg03468541

14

89029199

ZC3H14

TSS200

0.17

0.30

−0.13

0.004033

cg13526221

8

987389

 

-

0.79

0.69

0.11

0.004033

cg03313895

4

24803042

 

-

0.65

0.54

0.10

0.03549

cg19442593

2

26252851

 

-

0.85

0.74

0.11

0.004033

cg04851089

6

28953923

 

-

0.39

0.54

−0.15

0.004033

cg24520975

6

31651362

 

-

0.86

0.75

0.11

0.03549

cg01932076

21

47394659

 

-

0.18

0.30

−0.12

2.34E-05

cg17555825

5

76924190

 

-

0.16

0.26

−0.10

0.03549

cg23154781

15

80634195

 

-

0.81

0.69

0.12

0.004033

cg00792513

6

100066698

 

-

0.34

0.47

−0.14

0.03549

cg23708569

14

106058450

 

-

0.63

0.51

0.13

2.34E-05

cg09579989

12

110685438

 

-

0.81

0.71

0.10

0.03549

cg12077664

12

125145446

 

-

0.78

0.64

0.14

0.000358

cg24824082

2

133030701

 

-

0.24

0.35

−0.11

0.000358

  1. Dash indicates intergenic
  2. UTR untranslated region, TSS transcription start site
  3. aProbe ID on 450K chip
  4. bChromosome
  5. cGene annotated to probe
  6. dDifferential-methylated score
  7. e p value for specified probe in CD8+ T cells
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Clinical Epigenetics

ISSN: 1868-7083

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