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Table 1 MS-associated CpGs in CD8+ T cells

From: Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients

Probe IDa CHRb Position Genec Feature Median (case) Median (control) Δ meth d p valuee
cg03431738 21 40031295 ERG 5′UTR 0.81 0.68 0.13 0.004033
cg12026095 19 49468461 FTL TSS200 0.30 0.49 −0.18 0.004033
cg26228123 14 73392919 DCAF4 TSS200 0.09 0.20 −0.11 0.004033
cg10478035 13 80919503   - 0.75 0.64 0.11 0.004033
cg04474988 10 131770171   - 0.34 0.46 −0.11 0.03549
cg25152348 22 50946712 NCAPH2 1st exon 0.30 0.47 −0.17 0.03549
cg08206623 11 2907334 CDKN1C TSS1500 0.29 0.44 −0.15 0.004033
cg13738615 9 109624741 ZNF462 TSS1500 0.18 0.31 −0.13 0.004033
cg01525244 22 39548611 CBX7 TSS200 0.14 0.24 −0.10 0.004033
cg12702165 12 95228136 MIR492 TSS200 0.65 0.54 0.11 0.004033
cg06443542 10 100206752 HPS1 TSS200 0.14 0.25 −0.11 0.03549
cg00380172 6 148663585 SASH1 TSS200 0.21 0.33 −0.12 0.03549
cg19095187 6 108437051   - 0.17 0.31 −0.14 0.03549
cg04488145 3 46899455 MYL3 3′UTR 0.83 0.73 0.11 0.03549
cg03027241 20 49620453 KCNG1 3′UTR 0.50 0.32 0.18 0.004033
cg11700985 10 82127205 DYDC2 3′UTR 0.85 0.74 0.11 0.03549
cg07886142 5 126793022 MEGF10 3′UTR 0.59 0.46 0.13 0.03549
cg18183163 2 171574141 SP5 3′UTR 0.12 0.26 −0.14 0.03549
cg01181415 12 16757954 LMO3 5′UTR 0.22 0.36 −0.14 0.03549
cg10143811 12 16757985 LMO3 5′UTR 0.12 0.22 −0.10 0.03549
cg23274123 1 229478617 C1orf96 5′UTR 0.10 0.22 −0.12 0.004033
cg00095276 5 1068111 SLC12A7 Body 0.77 0.63 0.15 0.004033
cg03447557 1 2273735 MORN1 Body 0.80 0.70 0.10 0.03549
cg02745847 17 47075880 IGF2BP1 Body 0.17 0.31 −0.13 0.03549
cg09406795 11 64019655 PLCB3 Body 0.25 0.38 −0.13 0.000358
cg18016288 13 95834131 ABCC4 Body 0.47 0.32 0.15 0.000358
cg14486346 2 102000131 CREG2 Body 0.78 0.66 0.12 0.03549
cg21937244 14 103406412 CDC42BPB Body 0.75 0.61 0.14 0.03549
cg11811840 2 234669166 UGT1A10 Body 0.84 0.72 0.12 0.03549
cg25756617 1 43734917 TMEM125 TSS1500 0.69 0.58 0.11 0.03549
cg03768916 10 49813307 ARHGAP22 TSS200 0.30 0.43 −0.14 0.004033
cg06524757 13 72441523 DACH1 TSS200 0.25 0.35 −0.11 0.03549
cg03168749 11 124413574 OR8B12 TSS200 0.82 0.68 0.14 0.03549
cg21276022 9 136390236 TMEM8C TSS200 0.74 0.61 0.13 0.004033
cg09851596 8 143545214 BAI1 TSS200 0.60 0.49 0.11 0.03549
cg25296222 11 2037173   - 0.76 0.65 0.11 0.03549
cg00878533 1 2848864   - 0.72 0.62 0.11 0.000358
cg03612700 17 18970610   - 0.64 0.52 0.12 0.004033
cg03310594 7 22704316   - 0.82 0.69 0.13 2.34E-05
cg05854694 14 61123243   - 0.12 0.22 −0.10 0.000358
cg12384499 15 89949617   - 0.19 0.31 −0.11 0.004033
cg22509113 2 91777482   - 0.41 0.51 −0.10 0.004033
cg10495084 15 96889416   - 0.24 0.36 −0.12 0.004033
cg18008019 13 100641646   - 0.10 0.23 −0.12 0.03549
cg12093775 13 112548065   - 0.15 0.26 −0.11 0.000358
cg12787323 10 119494959   - 0.16 0.27 −0.11 0.004033
cg22792862 14 67827087 EIF2S1 1st exon 0.23 0.38 −0.15 0.004033
cg08969532 10 99790438 CRTAC1 1st exon 0.05 0.15 −0.10 0.004033
cg18185028 3 154042079 DHX36 1st exon 0.30 0.41 −0.11 0.000358
cg23059965 19 50655862 C19orf41 3′UTR 0.81 0.70 0.11 0.004033
cg02192678 8 1495185 DLGAP2 5′UTR 0.78 0.68 0.11 0.004033
cg02976009 6 32068226 TNXB 5′UTR 0.71 0.59 0.12 0.03549
cg18073471 4 81119198 PRDM8 5′UTR 0.18 0.29 −0.11 0.03549
cg00945810 7 814391 HEATR2 Body 0.67 0.56 0.11 0.03549
cg04875614 4 2008706 WHSC2 Body 0.80 0.69 0.10 2.34E-05
cg26920627 1 7319248 CAMTA1 Body 0.75 0.63 0.12 0.004033
cg26647242 2 30040525 ALK Body 0.78 0.67 0.11 0.004033
cg04605816 20 62092443 KCNQ2 Body 0.83 0.71 0.12 0.004033
cg10944063 2 120233706 SCTR Body 0.58 0.46 0.12 0.004033
cg14595269 7 151216272 RHEB Body 0.14 0.24 −0.10 2.34E-05
cg23720125 5 177097760 LOC202181 Body 0.85 0.73 0.12 0.004033
cg02047661 3 51976883 RRP9 TSS1500 0.64 0.52 0.11 0.004033
cg07925549 12 52828840 KRT75 TSS1500 0.75 0.63 0.12 0.03549
cg06697094 17 54911185 DGKE TSS1500 0.16 0.28 −0.12 0.03549
cg18789663 1 242688591 PLD5 TSS1500 0.09 0.20 −0.11 0.03549
cg03468541 14 89029199 ZC3H14 TSS200 0.17 0.30 −0.13 0.004033
cg13526221 8 987389   - 0.79 0.69 0.11 0.004033
cg03313895 4 24803042   - 0.65 0.54 0.10 0.03549
cg19442593 2 26252851   - 0.85 0.74 0.11 0.004033
cg04851089 6 28953923   - 0.39 0.54 −0.15 0.004033
cg24520975 6 31651362   - 0.86 0.75 0.11 0.03549
cg01932076 21 47394659   - 0.18 0.30 −0.12 2.34E-05
cg17555825 5 76924190   - 0.16 0.26 −0.10 0.03549
cg23154781 15 80634195   - 0.81 0.69 0.12 0.004033
cg00792513 6 100066698   - 0.34 0.47 −0.14 0.03549
cg23708569 14 106058450   - 0.63 0.51 0.13 2.34E-05
cg09579989 12 110685438   - 0.81 0.71 0.10 0.03549
cg12077664 12 125145446   - 0.78 0.64 0.14 0.000358
cg24824082 2 133030701   - 0.24 0.35 −0.11 0.000358
  1. Dash indicates intergenic
  2. UTR untranslated region, TSS transcription start site
  3. aProbe ID on 450K chip
  4. bChromosome
  5. cGene annotated to probe
  6. dDifferential-methylated score
  7. e p value for specified probe in CD8+ T cells