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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Promoter methylation status and expression of PPAR-γ gene are associated with prognosis of acute-on-chronic hepatitis B liver failure

Fig. 1

Methylation status of PPAR-γ promoter and comparison of PPAR-γ mRNA expression level. a The methylation frequency of PPAR-γ promoter in acute-on-chronic hepatitis B liver failure (ACHBLF) patients was significantly decreased compared with chronic hepatitis B (CHB) patients but was significantly higher than healthy controls (HC). b For CpG-1 island, products of methylation-specific PCR (MSP) are displayed. 218 bp M lanes and 221 bp U lanes. M for methylation state of CpG island on PPAR-γ promoter, U for unmethylation state, N for negative control. c For CpG-2 island, products of MSP are displayed. 138 bp M lanes and 139 U lanes. For both CpG-1 (d) and CpG-2 (e) islands, PPAR-γ mRNA expression level was significantly lower in methylated group than that in unmethylated group. f mRNA level was decreased stepwise as methylated CpG islands added. *P < 0.05, **P < 0.01

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Clinical Epigenetics

ISSN: 1868-7083

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