Table 3 Uni-and multivariate Cox regression analysis of BCR in ERG stratified PC patient subsets

Variable

HR (95 % CI)

p value

C-index

HR (95 % CI)

p value

HR (95 % CI)

p value

C-index^c

C-index^d

 5hmC score (cont.)

1.97 (1.19–3.26)

0.008

0.62

2.02 (1.16–3.51)

0.013

2.08 (1.22–3.52)

0.007

0.73

 Pre-op. PSA (≤10 vs. >10 ng/ml)

2.66 (1.44–4.92)

0.002

0.60

2.36 (1.26–4.44)

0.008

2.62 (1.41–4.87)

0.002

0.68

 Surgical margin (neg. vs. pos.)

2.83 (1.69–4.72)

<0.001

0.62

2.51 (1.42–4.44)

0.001

2.80 (1.67–4.68)

<0.001

 Tumor stage (pT2 vs. pT3-4)

2.26 (1.35–3.78)

0.002

0.62

1.35 (0.74–2.45)

0.328

–

–

 Gleason score (<7 vs. ≥7)

2.22 (1.01–4.88)

0.048

0.56

1.82 (0.81–4.10)

0.147

–

–

Variable

HR (95 % CI)

p value

C-index

HR (95 % CI)

p value

HR (95 % CI)

p value

C-index^c

C-index^d

 5hmC score (cont.)

1.22 (0.77–1.94)

0.398

0.52

1.44 (0.90–2.30)

0.129

–

–

NA

 Pre-op. PSA (≤10 vs. >10 ng/ml)

3.19 (1.96–5.20)

<0.001

0.65

1.93 (1.12–3.32)

0.017

2.03 (1.26–3.25)

0.004

0.76

 Surgical margin (neg. vs. pos.)

2.91 (1.86–4.54)

<0.001

0.63

1.73 (1.07–2.82)

0.026

1.94 (1.25–3.01)

0.003

 Tumor stage (pT2 vs. pT3-4)

3.65 (2.35–5.68)

<0.001

0.65

2.35 (1.41–3.91)

0.001

2.13 (1.36–3.35)

0.001

 Gleason score (<7 vs. ≥7)

3.04 (1.76–5.27)

<0.001

0.61

2.23 (1.24–4.01)

0.007

2.76 (1.63–4.68)

<0.001