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Table 2 Uni-and multivariate Cox regression analysis of BCR in the full PC patient set

From: High levels of 5-hydroxymethylcytosine (5hmC) is an adverse predictor of biochemical recurrence after prostatectomy in ERG-negative prostate cancer

 

All PCs (n = 311, 143 BCR)

 

Univariate

Multivariatea

Multivariateb

Variable

HR (95 % CI)

p value

C-index

HR (95 % CI)

p value

HR (95 % CI)

p value

C-indexc

C-indexd

5hmC score (cont.)

1.53 (1.09–2.15)

0.013

0.57

1.58 (1.12–2.23)

0.009

1.62 (1.15–2.28)

0.006

0.75

 

Pre-op. PSA (≤10 vs. >10 ng/ml)

2.93 (2.00–4.29)

<0.001

0.63

2.17 (1.46–3.24)

<0.001

2.17 (1.46–3.24)

<0.001

 

0.75

Surgical margin (neg. vs. pos.)

2.86 (2.04–4.00)

<0.001

0.63

1.99 (1.38–2.86)

<0.001

1.99 (1.38–2.86)

<0.001

  

Tumor stage (pT2 vs. pT3-4)

2.96 (2.13–4.13)

<0.001

0.64

1.91 (1.32–2.76)

0.001

1.90 (1.32–2.75)

0.001

  

Gleason score (≤6 vs. >6)

2.67 (1.70–4.17)

<0.001

0.58

2.08 (1.30–3.34)

<0.002

2.02 (1.26–3.23)

0.003

  

ERG status (neg. vs. pos.)

1.06 (0.76–1.48)

0.732

0.51

1.19 (0.85–1.68)

0.314

–

–

  
  1. Significant p values (p < 0.05) are highlighted in bold
  2. aGlobal multivariate model including all parameters
  3. bFinal multivariate model including significant variables only
  4. cHarrell’s C-index for final model including 5hmC
  5. dHarrell’s C-index for final model excluding 5hmC