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Table 1 Gains and losses of DNA methylation at imprinted loci in HCC

From: Loss of DNA methylation at imprinted loci is a frequent event in hepatocellular carcinoma and identifies patients with shortened survival

  

Tumor

Adjacent

  

Loss

Gain

Loss + gain

Loss

Gain

Loss + gain

DIRAS3(3)

1p31

+

     

DIRAS3(2)

1p31

++

++

•

++

++

•

ZBDF2

2q33

++

+

    

NAP1L5

4q22

++

++

•

++

++

•

ZAC

6q24

(+)

  

(+)

  

SLC22A3

6q26

+

+

•

   

GRB10

7p12

      

PEG10

7q21

      

MEST

7q32

      

H19DMR

11p15.5

++

+

•

   

IFG2(0)

11p15.5

++

     

IGF2(2)

11p15.5

++

     

KCNQ1DN

11p15

 

++

    

KvDMR

11p15

(+)

  

(+)

  

RB1

13q14

++

++

•

   

DLK1p

14p32

      

IGDMR(1)

14q32

++

     

IGDMR(2)

14q32

+

     

MEG3DMR(1)

14q32

++

+

•

   

MEG3DMR(2)

14q32

++

+

•

   

MEG3DMR(3)

14q32

++

+

•

   

MKRN3

15q11

++

     

MAGEL2

15q11

++

  

+

  

NDN

15q11

(+)

     

SNRPN

15q11

++

+

•

   

GABRB3

15q11

++

  

+

  

NLRP2

19q13

++

(+)

(•)

   

PEG3

19q13

 

+

    

USP29

19q13

+ +

     

ZIM3

19q13

+ +

     

NNAT

20q11

      

L3MBTL

20q13

 

(+)

    

GNAS-XL

20q13

++

++

•

   

NESP

20q13

++

++

•

   
 

Sum

23 (+3)

14 (+2)

11

4 (+2)

2

2

  1. The DNA methylation levels for all loci presented in Fig. 1 are classified after visual inspection of the data. The loci are arranged according to their chromosomal localisation
  2. (+) slight alterations, + alterations, ++ strong alterations,• gain + loss at the same locus