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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

Fig. 5

Putative mechanism of action involved in the restoration of pathological signs by the simultaneous inhibition of HDACs and PDE5. HDAC histone deacetylase, Ac acetyl, PDE phosphodiesterase, PKG protein kinase G, LTP long-term potentiation, inhibition, activation

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Clinical Epigenetics

ISSN: 1868-7083

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