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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

Fig. 2

A synergistic effect was observed with the combination of vorinostat and tadalafil on long-term potentiation (LTP) in APP/PS1 mice slices. a Relative fPSP slope (from basal values) versus time in hippocampal APP/PS1-positive slices. Orange vertical bar denotes time for vorinostat (2 μM ) and/or tadalafil (50 nM) incubation; arrow corresponds to the high-frequency stimulation (HFS) protocol. b Average relative changes of fPSP slope before and 60 min after HFS in control (dark grey; n = 6) and vorinostat (green; n = 5), tadalafil (light grey; n = 4), and vorinostat and tadalafil (combination, blue; n = 5) treatments. c Relative fPSP slope (from basal values) versus time in APP/PS1-negative slices in control (black) and the combination of vorinostat and tadalafil (blue) conditions. Orange vertical bar denotes time for the combination of vorinostat and tadalafil (combination) incubation; arrow corresponds to HFS. d Average relative changes of fPSP slope before (open bars) and 60 min after HFS (filled bars) in control (black) and combination treatment (blue) in APP/PS1-negative mice (n = 8 and 3 slices, respectively); *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Data are represented as means ± SEM

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Clinical Epigenetics

ISSN: 1868-7083

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