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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer

Fig. 2

HOTAIR mediates recurrence and progression in NMIBC. a qPCR analyses showing the expression of HOTAIR in NMIBC samples according the tumor recurrence. b Kaplan-Meier analysis showing that patients with higher HOTAIR expression (according the median) showed an earlier recurrence (p value was obtained by the log-rank test). c Heat map showing the distribution of genes (rows) and samples following unsupervised clustering (Pearson correlation and average linkage method) of 28 tumors and 10 normal samples [16] according the expression of genes previously identified by the binding of HOTAIR-EZH2 complexes [7, 24]. A red (overexpressed) to blue (downregulated) scheme following the above scale limits (in log2 scale) is shown. Note that recurrent and non-recurrent tumors, besides of non-tumor bladder tissue, could be efficiently discriminated. d qPCR analyses showing the expression of HOTAIR in recurrent NMIBC samples according the tumor progression. e Kaplan-Meier analysis showing that patients with higher HOTAIR expression (according the median) showed an earlier progression upon recurrence (p value was obtained by the log-rank test)

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