Fig. 2
From: Selective increase in subtelomeric DNA methylation: an epigenetic biomarker for malignant glioma
The difference in subtelomeric DNA methylation ratio, as obtained from MSP between control and glioma patients were found significant for Chr. 18p (c), 21q (d), and XpYp (e). In contrast, insignificant alteration in methylation ratio was observed at the subtelomere of Chr. 7q (a) and 8q (b). The change in subtelomeric methylation level was cross-validated with pyrosequencing analysis. In comparison to MSP, pyrosequencing data revealed significant change in average methylation level at Chr. 8q (g), 21q (i), and XpYp (j) but insignificant methylation alteration for Chr. 7q (f) and 18p (h)