Fig. 4
From: Circulating nucleosomes as epigenetic biomarkers in pancreatic cancer
ROC curve for discrimination of cancer vs. healthy. The area under the curve for an optimal panel of five nucleosomal biomarkers (0.95) selected from a panel of nine was significantly higher than that of CA 19-9 (0.87), the current gold standard for pancreatic cancer. As for discrimination of cancer vs. healthy and benign, the AUC was further improved by replacing the lowest weighted nucleosomal biomarker in model 1 with CA 19-9 in a panel with the four nucleosomal biomarkers (0.98) to give a second, mixed biomarker, model