Fig. 3
From: Circulating nucleosomes as epigenetic biomarkers in pancreatic cancer
Discrimination of four NuQ® assay panel combined with CA 19-9 for pancreatic cancer, benign disease, and healthy controls. Improved separation between the pancreatic cancer (n = 25), the benign samples (n = 10), and healthy controls (n = 24) was achieved with pre-processed ELISA data from four nucleosomal biomarkers combined with CA 19-9. A linear model (Fisher’s linear discriminant) was used to generate a weighted sum of values assigned as arbitrary units (AU) = −0.788 (5MC) − 2.338 (H2AZ) + 1.959 (H2A1.1) + 0.672 (H3K4Me2) + 0.782 (CA 19-9). P value was determined by the Mann-Whitney U test. Box plots indicate the median and 25th and 75th percentiles. Whiskers indicate the 5th and 95th percentiles