From: Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer
Study | Analyzed CpGs | Cohort | Hypermethylatedc | Hypomethylatedd |
---|---|---|---|---|
Matched tumor tissue panel (bisulfite sequencing)a | −290 to +117 | All patients (n = 21) | 13 (61.90 %) | 4 (19.05 %) |
22 CpGs | ||||
Grade 1 (n = 5) | 5 (100.00 %) | 0 (0.00 %) | ||
Grade 2 (n = 11) | 6 (54.55 %) | 3 (27.27 %) | ||
Grade 3 (n = 2) | 1 (50.00 %) | 1 (50.00 %) | ||
GSE20713 Methylation data (microarray analysis)b | −571 and 455 | All patients (n = 338) | 213 (63.02 %) | 3 (0.89 %) |
2 CpGs | ||||
Grade 1 (n = 64) | 41 (64.06 %) | 0 (0.00 %) | ||
Grade 2 (n = 57) | 35 (61.40 %) | 1 (1.75 %) | ||
Grade 3 (n = 215) | 135 (62.79 %) | 2 (0.01 %) |