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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Transgelin gene is frequently downregulated by promoter DNA hypermethylation in breast cancer

Fig. 4

Methylation status of TAGLN in public datasets GSE20713 and GSE31979. a Graphs showing higher normalized average methylation scores (NAMS) for two probes of TAGLN in tumor tissues Mann–Whitney test, ****P < 0.0001. Horizontal lines: mean ± SEM. b Scatter plot showing correlation of average methylation scores of TAGLN probes (GSE20713) to average expression (log2) of TAGLN probe sets (GSE20711); Spearman r = −0.5442, P < 0.0001. c ROC analyses for discrimination between healthy individuals and breast cancer patients, using TAGLN NAMSs. d Kaplan-Meier (KM) survival analysis showing higher RFS percentages for patients with tumor TAGLN NAMSs ≤80 (best cutoff among tested)

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